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首页> 外文期刊>Crystal growth & design >Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level
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Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level

机译：分子水平上位错驱动的生长和六角形L-胱氨酸结晶的抑制。

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Crystallization of L-cystine is a critical process in the pathogenesis of kidney stone formation in cystinuria, a disorder affecting more than 20 000 individuals in the United States alone. In an effort to elucidate the crystallization of L-cystine and the mode of action of tailored growth inhibitors that may constitute effective therapies, real-time in situ atomic force microscopy has been used to investigate the surface micromorphology and growth kinetics of the {0001} faces of L-cystine at various supersaturations and concentrations of the growth inhibitor L-cystine dimethylester (CDME). Crystal growth is actuated by screw dislocations on the {0001} L-cystine surface, producing hexagonal spiral hillocks that are a consequence of six interlacing spirals of anisotropic molecular layers. The high level of elastic stress in the immediate vicinity around the dislocation line results in a decrease in the step velocities and a corresponding increase in the spacing of steps. The kinetic curves acquired in the presence of CDME conform to the classical CabreraVermilyea model. Anomalous birefringence in the {10 (1) over bar0} growth sectors, combined with computational modeling, supports a high fidelity of stereospecific binding of CDME, in a unique orientation, exclusively at one of the six crystallographically unique projections on the {10 (1) over bar0} plane.
机译：L-胱氨酸的结晶是胱氨酸尿症肾结石形成的发病机理中的关键过程，仅在美国，这种疾病就影响了2万多人。为了阐明L-胱氨酸的结晶和可能构成有效疗法的特制生长抑制剂的作用方式，实时原位原子力显微镜已用于研究{0001}的表面微观形貌和生长动力学生长抑制剂L-胱氨酸二甲基酯（CDME）的各种过饱和度和浓度下的L-胱氨酸表面。晶体生长是由{0001} L-胱氨酸表面上的螺旋位错驱动的，产生了六边形螺旋小丘，这是六个各向异性分子层的交错螺旋的结果。在位错线附近的高水平弹性应力导致阶梯速度的减小和阶梯间距的相应增加。在CDME存在下获得的动力学曲线符合经典的CabreraVermilyea模型。 {10（1）在bar0}生长区的反常双折射与计算模型相结合，支持CDME立体定向结合的高保真度，且方向独特，仅在{10（1）（1）上六个晶体学上唯一的投影之一上）在bar0}平面上。

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