Insight into the Phase Transformation among Various Solid Forms of Baicalein

Zhu Bingqing; Wang Jian-Rong; Mei Xuefeng

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Insight into the Phase Transformation among Various Solid Forms of Baicalein

机译：黄ical素各种固体形式之间的相变研究

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A new polymorph and three hydrates of baicalein, a widely prescribed anti-inflammatory TCM drug, were discovered through comprehensive polymorph screening experiments. The forms were fully characterized by a range of analytical techniques, including PXRD, Raman spectra, FTIR, HSM, SEM, TGA, DSC, and DVS. Single crystal structures and the transformation pathways among different polymorphs and hydrates are discussed in detail. Single-crystal-to-single-crystal transformation behavior between monohydrate and hemihydrate was revealed. Thermodynamic stability, hygroscopicity, and powder dissolution behavior were investigated. The results show that the newly discovered form gamma presents better dissolution behavior and remarkably greater apparent solubility compared with the current widely used marketed drug substance.

机译：通过全面的多晶型物筛选实验，发现了一种新的多晶型物和黄ical素的三种水合物，黄ical素是一种处方广泛的抗炎中药。通过多种分析技术，包括PXRD，拉曼光谱，FTIR，HSM，SEM，TGA，DSC和DVS，对这些形式进行了全面表征。详细讨论了单晶结构以及不同多晶型物和水合物之间的转化途径。揭示了单水合物和半水合物之间的单晶至单晶转变行为。研究了热力学稳定性，吸湿性和粉末溶解行为。结果表明，与当前广泛使用的市售药物相比，新发现的伽马形式具有更好的溶解行为和明显更高的表观溶解度。

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《Crystal growth & design》 |2015年第10期|共10页
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Zhu Bingqing; Wang Jian-Rong; Mei Xuefeng;
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1. Insight into the Phase Transformation among Various Solid Forms of Baicalein [J] . Zhu Bingqing, Wang Jian-Rong, Mei Xuefeng Crystal growth & design . 2015,第10期

机译：黄ical素各种固体形式之间的相变研究
2. Versatile solid forms of boscalid: insight into the crystal structures and phase transformations [J] . Li Zhonghua, Jia Lina, Shi Peng, CrystEngComm . 2019,第44期

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3. Tracking Sodium-Antimonide Phase Transformations in Sodium-Ion Anodes: Insights from Operando Pair Distribution Function Analysis and Solid-State NMR Spectroscopy [J] . Phoebe K. Allan, John M. Griffin, Ali Darwiche, Journal of the American Chemical Society . 2016,第7期

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4. Solid-Solid Phase Transformations in Aluminium Alloys Described by a Multiphase-Field Model [C] . International Conference on Solidification and Gravity . 2006

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5. Quantum Chain Reactions and delta-Hydrogen Abstraction of Aromatic Ketones: Insights into Solid to Solid Transformations and Efficiency in Crystals. [D] . Nielsen, Amy. 2014

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6. TrackingSodium-Antimonide Phase Transformations inSodium-Ion Anodes: Insights from Operando Pair Distribution FunctionAnalysis and Solid-State NMR Spectroscopy [O] . PhoebeK. Allan, John M. Griffin, Ali Darwiche, -1

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7. Nonlinear wave mechanisms of very fast chemical and phase transformations in solids. applications to cosmic chemistry processes near to 0 k, to explosive-like decays of metastable solid phases and to catastrophic geotectonic phenomena [O] . Viktor Barelko, Dmitryi Kiryukhin, Igor Barkalov, 2010

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Insight into the Phase Transformation among Various Solid Forms of Baicalein

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