Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine

Bhatt PM; Azim Y; Thakur TS; Desiraju GR

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Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine

机译：抗艾滋病毒药物拉米夫定和齐多夫定的共晶体

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Co-crystal forming abilities of the two anti-HIV drugs lamivudine and zidovudine were studied. A study of five crystal structures was carried out to investigate the general applicability of the retrosynthetic approach in the design of new co-crystals. This analysis of co-crystals and salt structures showed a complete to partial success, and in one case, a total failure to obtain the predicted synthon. Both screening strategies and rerrosynthetic methods may be appropriate for the discovery of new active pharmaceutical ingredients co-crystals.

机译：研究了两种抗艾滋病毒药物拉米夫定和齐多夫定的共晶形成能力。对五个晶体结构进行了研究，以研究逆向合成方法在新共晶体设计中的一般适用性。这种对共晶体和盐结构的分析显示出完全成功或部分成功，而在一种情况下，则完全无法获得预期的合成子。筛选策略和反式合成方法都可能适合发现新的活性药物成分共晶体。

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《Crystal growth & design》 |2009年第2期|共7页
作者
Bhatt PM; Azim Y; Thakur TS; Desiraju GR;
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正文语种 eng
中图分类晶体学;
关键词
ACTIVE PHARMACEUTICAL INGREDIENTS; ORGANIC MOLECULAR-CRYSTALS; SOLID-STATE; CARBOXYLIC-ACIDS; SUPRAMOLECULAR SYNTHESIS; TERNARY COCRYSTALS; DESIGN; COMPLEXES; WATER; SYNTHON;

机译：活性药物成分;有机分子晶体;固态;羧酸;超分子合成;三级结晶;设计;化合物;水;合成;

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1. Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine [J] . Bhatt PM, Azim Y, Thakur TS, Crystal growth & design . 2009,第2期

机译：抗艾滋病毒药物拉米夫定和齐多夫定的共晶体
2. Viral Rebound and Emergence of Drug Resistance in the Absence of Viral Load Testing: A Randomized Comparison between Zidovudine-Lamivudine plus Nevirapine and Zidovudine-Lamivudine plus Abacavir [J] . Nicasie Ndembi, Ruth L. Goodall, David T. Dunn, Journal of Infectious Diseases . 2010,第1期

机译：在没有病毒载量测试的情况下病毒反弹和耐药性的出现：齐多夫定-拉米夫定加奈韦拉平和齐多夫定-拉米夫定加阿巴卡韦之间的随机比较
3. Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). [J] . Gibb DM, Walker AS, Kaye S, Antiviral therapy . 2002,第4期

机译：在未使用抗逆转录病毒的HIV-1感染的儿童中，用abacavir / lamivudine，zidovudine / lamivudine或abacavir / zidovudine联合或不联合nelfinavir治疗的儿童中抗逆转录病毒表型和基因型耐药性的演变（PENTA 5试验）。
4. Assay Development Challenges for Determination of Abacavir, Darunavir, Etravirine, Lamivudine, Nevirapine, Saquinavir, Stavudine, and Zidovudine in Human Plasma by LC/MS/MS [C] . Spencer Carter, Brad Bessette, Benjamin Smith, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：LC / MS / MS测定Abacavir，Darunavir，etravirine，Lamivudine，Nevirapine，Saquinavir，Stavudine和Zidovudine的测定挑战
5. Intracellular drug -drug interaction between nucleoside analogs leads to early virologic failure in HIV patients receiving triple nucleoside combinations of tenofovir, lamivudine and abacavir or didanosine. [D] . Bi, Lucun. 2007

机译：核苷类似物之间的细胞内药物相互作用会导致接受替诺福韦，拉米夫定和阿巴卡韦或二羟肌苷的三核苷组合的HIV患者出现早期病毒学衰竭。
6. Clinical Immunological and Virological Responses of Zidovudine-Lamivudine-Nevirapine versus Zidovudine-Lamivudine-Efavirenz Antiretroviral Treatment (ART) Among HIV-1 Infected Children: Asella Teaching and Referral Hospital South-East Ethiopia [O] . Abebe Sorsa 2018

机译：在HIV-1感染儿童中齐多夫定-拉米夫定-尼维拉平与齐多夫定-拉米夫定-依非韦伦抗逆转录病毒治疗（ART）的临床免疫学和病毒学应答：东南埃塞俄比亚阿塞拉教学与转诊医院
7. Prenatal exposure to anti-HIV drugs: Neurobehavioral effects of zidovudine (AZT) + lamivudine (3TC) treatment in mice [O] . Aldina Venerosi, Angela Valanzano, Enrico Alleva, 2001

机译：产前暴露于抗HIV药物：Zidovudine（AZT）+ Lamivudine（3Tc）治疗的神经衰弱作用

Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine

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