Formation Kinetics and Stability of Carbamazepine-Nicotinamide Cocrystals Prepared by Mechanical Activation

Chieng N; Hubert M; Saville D; Rades T; Aaltonen J

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Formation Kinetics and Stability of Carbamazepine-Nicotinamide Cocrystals Prepared by Mechanical Activation

机译：机械活化法制备卡马西平-烟酰胺共晶体的形成动力学和稳定性

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Co-milling of various carbamazepine (CBZ) polymorphic forms (form I, III and dihydate) with nicotinamide (NIC) was performed in this Study to investigate the formation kinetics of carbamazepine-nicotinamide cocrystals (CBZ-NIC) and to evaluate their physical stability. Milling was carried out at room temperature using an oscillatory ball mill at a 1:1 molar ratio of CBZ and NIC for various times up to 60 min. A freshly prepared sample was used for each milling. In the stability study, the milled samples (4, 10, 15, and 30 min) were stored under four conditions (20 and 40 degrees C

机译：在这项研究中，将各种卡马西平（CBZ）多晶型物（形式I，III和二氢酸盐）与烟酰胺（NIC）共同研磨，以研究卡马西平-烟酰胺共晶体（CBZ-NIC）的形成动力学，并评估其物理稳定性。。使用振荡式球磨机在室温下以CBZ和NIC的摩尔比为1：1进行研磨长达60分钟。新鲜制备的样品用于每次研磨。在稳定性研究中，研磨后的样品（4、10、15和30分钟）在四种条件下（20和40摄氏度）存储

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《Crystal growth & design》 |2009年第5期|共10页
作者
Chieng N; Hubert M; Saville D; Rades T; Aaltonen J;
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正文语种 eng
中图分类晶体学;
关键词
PHARMACEUTICAL PHASES; AMORPHOUS PHASE; SOLID-STATE; CO-CRYSTAL; POLYMORPHS; CALORIMETRY; DISSOLUTION; PRODUCT; DRUG; FORM;

机译：药物相;非晶相;固态;共结晶;聚合物;量热法;溶解度;产品;药物;形式;

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1. Formation Kinetics and Stability of Carbamazepine-Nicotinamide Cocrystals Prepared by Mechanical Activation [J] . Chieng N, Hubert M, Saville D, Crystal growth & design . 2009,第5期

机译：机械活化法制备卡马西平-烟酰胺共晶体的形成动力学和稳定性
2. Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. [J] . Chieng N, Aaltonen J, Saville D, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2009,第1期

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3. Phase State and Thermal Stability of Powders Prepared by Mechanical Activation of Iron in an Organosilicon Solution [J] . S. F. Lomaeva, N. V. Ivanov, E. P. Yelsukov Colloid journal . 2004,第2期

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4. Using terahertz time-domain-spectroscopy to follow the kinetics and mechanism of cocrystal formation [C] . Parrott Edward P.J., Zeitler J. Axel, Frisci Tomislav, International Conference on Infrared, Millimeter and Terahertz Waves . 2008

机译：使用Terahertz时域 - 光谱检查通过COCRYSTAL形成的动力学和机制
5. Kinetic driving effects of phase transformations in mechanically activated powders. [D] . Zhang, Yan. 2013

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7. Chemical and Mechanical Stability of the High-Tc Phase in the Bi-Pb-Sr-Ca-Cu-O System. (IV). Formation of the High-Tc Phase in Amorphous Powder Prepared by Mechanical Grinding. [O] . Yoshihiro Kusano, Toshinobu Niinae, Tokuro Nanba, 1993

机译：Bi-PB-SR-CA-CU-O系统中高TC相的化学和机械稳定性。（iv）。通过机械研磨制备的无定形粉末形成高TC相。

Formation Kinetics and Stability of Carbamazepine-Nicotinamide Cocrystals Prepared by Mechanical Activation

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