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Promoting resilience through neurocognitive functioning in youth living with HIV

机译：通过艾滋病毒患者的青春神经认知功能促进弹性

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摘要

Using a phased model of intervention development, we developed an intervention to promote resilience in youth living with HIV via improved neurocognitive resources. First, youth completed a naturalistic prospective memory (PM) task and were randomized into a visualization condition or control condition. Next, 47 of these participants completed another naturalistic PM task and were randomized into Calendaring condition, an Alarm condition, a Combined condition, or a Control condition. Youth with low PM demonstrated observable gains from the visualization technique. Youth in the Combined Calendaring and Alarm condition demonstrated significantly better performance than participants in the Control and Calendaring conditions. In a Proof-of-Concept study with 16 youth, the previous findings were translated into a single session in-person intervention followed by tailored text messaging to improve adherence and viral load via improved neurocognitive resources. The resulting intervention showed a signal of effect with viral load reductions in youth with available data. Targeting compensatory strategies to enhance neurocognitive functioning may promote resilience and health outcomes. A randomized pilot study with a control condition is the next step.
机译：使用逐步的干预发展模型，我们制定了一种干预，以通过改善的神经认知资源促进艾滋病毒的青少年恢复力。首先，青年完成了自然主义潜记忆（PM）任务，并随机被随机化为可视化条件或控制条件。接下来，这些参与者中的47名完成了另一个自然主义的PM任务，并被随机分为日历条件，报警条件，组合条件或控制条件。低于PM的青年从可视化技术证明了可观察的收益。组合的日历和报警条件中的青年表现出比控制和日历条件的参与者的性能明显更好。在概念上具有16个青年的概念研究中，先前的发现被翻译成单一的干预课程，然后定制了短信，以通过改进的神经认知资源改善依从性和病毒载量。由此产生的干预显示了具有可用数据的青少年病毒载量的效果的效果。针对增强神经认知功能的补偿策略可能促进弹性和健康结果。具有控制条件的随机试验研究是下一步。

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