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首页> 外文期刊>AIDS care. >Single tablet HIV regimens facilitate virologic suppression and retention in care among treatment naive patients
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Single tablet HIV regimens facilitate virologic suppression and retention in care among treatment naive patients

机译：单片艾滋病毒治疗方案促进病毒学抑制和保留治疗幼稚患者

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Newer HIV regimens are typically taken once daily but vary in the number of pills required. Whether the number of pills in a once-daily HIV regimen affects clinical outcomes is unknown. We retrospectively compared adherence, retention in care, and virologic outcomes between patients starting a once daily single-tablet regimen (STR) to patients starting a once-daily multi-tablet regimen (MTR) in a publicly funded clinic in the United States. Outcomes were measured in the year after starting ART and included retention in care, virologic suppression, and medication possession ratio of at least 80%. Data from patients initiating therapy from 1 January 2008 to 31 December 2011 were analyzed with both unadjusted and propensity-score adjusted regression. Overall, 622 patients started with an STR (100% efavirenz-based) and 406 with an MTR (65% atazanavir-based and 35% darunavir-based) regimen. Retention in care was achieved in 80.7% of STR patients vs. 72.7% of MTR patients (unadjusted OR 1.57, 95% CI 1.17-2.11; adjusted OR 1.49, 95% CI 1.10-2.02). Virologic suppression occurred among 84.4% of STR patients vs. 77.6% of MTR patients (unadjusted OR 1.56; 95% CI 1.14-2.15; adjusted OR 1.41; 95% CI 1.02-1.96). There was no difference in the proportion of patients achieving at least 80% adherence, as measured by medication possession ratio (33.0% of STR patients and 30.1% of MTR patients; unadjusted OR 1.14; 95% CI 0.87-1.50; adjusted OR 1.04, CI 0.79-1.38). While it is difficult to eliminate confounding in this observational study, retention in care and virologic outcomes were better in patients prescribed STRs.
机译：较新的HIV方案通常每天服用一次，但在所需的药丸数量中变化。曾经每日HIV方案中的药丸数量是否会影响临床结果是未知的。我们回顾性地比较了在美国公共资助的诊所起始的患者每日单片机方案（str）开始患者患者的依从性，保留治疗和病毒学结果。在起始艺术之后的一年中衡量结果，包括保健，病毒学抑制和药物占有率至少为80％的保留。从2008年1月1日至2011年12月31日开始治疗的患者的数据被分析，并不是未经调整的和倾向评分调整后的回归。总体而言，622名患者从STR（100％EFAVIREVEN）和406名患者，其中406例（65％ATAZANAVIR为基础，35％的Darunavir为基础）方案。在80.7％的STR患者中达到护理的保留率为72.7％（未调整的或1.57,95％CI 1.17-2.11;调整后的或1.49,95％CI 1.10-2.02）。病毒学抑制发生在84.4％的STR患者中，77.6％的MTR患者（未调整的或1.56; 95％CI 1.14-2.15;调整或1.41; 95％CI 1.02-1.96）。通过药物占有率（33.0％的STR患者的33.0％和MTR患者30.1％的33.0％;未调整的或1.14; 95％CI 0.87-1.50;调整后或1.04;调整或1.04;调整或1.04， CI 0.79-1.38）。虽然在这种观察性研究中难以消除混淆，但在规定的患者中，护理和病毒原因的保留和病毒学结果更好。

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