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首页> 外文期刊>AIDS care. >The association between HIV clinical disease severity and psychiatric disorders as seen in Western Romania
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The association between HIV clinical disease severity and psychiatric disorders as seen in Western Romania

机译：罗马尼亚西部艾滋病毒临床疾病严重程度和精神病疾病之间的关联

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HIV disease continues to be a serious health issue all over the world. By the end of 2016, 36.7 million people were living with HIV, 1.8 million people became newly infected and 1 million died of HIV-related causes/diseases. In order to develop effective treatment strategies, is important to assess the risk factors that affect negatively the HIV-positive patients. HIV-infected patients are at high risk of developing psychiatric disorders in every stage of the illness. Psychiatric disorders can negatively influence the treatment adherence, induce risk behavior and influence the quality of life. The purpose of this study is to determine if the severity of HIV disease is associated with increased frequency of psychiatric disorders. We evaluated 101 HIV-positive patients receiving antiretroviral therapy in Western Romania via Psychiatric Diagnostic Screening Questionnaire (PDSQ). We conducted a risk analysis in order to see if the patients have a higher risk of developing psychiatric disorders depending on HIV serostatus factor (HIV asymptomatic, symptomatic, AIDS converted). Our study shows that, the patients having AIDS and symptomatic HIV have a higher prevalence for the most common psychiatric disorders: major depressive disorder (OR=5.81;p0.001), panic disorder (OR=3.11; p=0.016), agoraphobia (OR=4.31; p=0.024), social phobia (OR=2.81; p=0.038), generalized anxiety disorder (OR=4.79; p=0.006), somatization (OR=8.72; p0.0010) and hypochondria (OR=4.66; p=0.0013). Symptomatic HIV and AIDS converted serostatus is also a risk factor for post-traumatic stress disorder, obsessive-compulsive disorder and psychosis. The main conclusion of this study is that the more severe HIV clinical disease was associated with increased frequency of psychiatric disorders. As a consequence, we conclude that psychiatric disorders and HIV/AIDS treatment should be addressed simultaneously, depending on the risk specific factors such as the HIV infection stage and, due to psychiatric repercussions of HIV is expected to become more relevant in the coming years.
机译：艾滋病毒疾病仍然是世界各地的严重健康问题。截至2016年底，3670万人患有艾滋病毒，180万人成为新感染，100万人死于艾滋病毒相关的原因/疾病。为了开发有效的治疗策略，重要的是评估对艾滋病毒阳性患者产生负面影响的风险因素。艾滋病毒感染的患者在疾病的每一阶段都有高风险的开发精神疾病。精神疾病可以对治疗依从性产生负面影响，诱导风险行为并影响生活质量。本研究的目的是确定HIV病的严重程度是否与精神疾病的频率增加有关。我们通过精神诊断筛查问卷（PDSQ）评估了101例接受西罗马尼亚抗逆转录病毒治疗的艾滋病毒阳性患者。我们进行了风险分析，以便根据HIV Serostatus因子（艾滋病病毒无症状，转化的艾滋病），患者是否具有更高的开发精神疾病的风险。我们的研究表明，患有艾滋病和症状性艾滋病毒的患者对最常见的精神病疾病具有更高的流行：主要抑郁症（或= 5.81; P <0.001），恐慌症（或= 3.11; P = 0.016），广播恐惧症（或= 4.31; p = 0.024），社交恐惧症（或= 2.81; p = 0.038），广义焦虑症（或= 4.79; p = 0.006），躯体化（或= 8.72; p <0.0010）和次粒细胞（或= 4.66 ; p = 0.0013）。症状艾滋病毒和艾滋病转化后血清肿也是创伤后应激障碍，强迫性疾病和精神病的危险因素。本研究的主要结论是，更严重的艾滋病毒临床疾病与精神疾病的频率增加有关。因此，我们得出结论，应同时解决精神病疾病和艾滋病毒/艾滋病治疗，具体取决于艾滋病毒感染阶段等风险特异性因素，由于艾滋病毒的精神病学反应，预计未来几年将变得更加相关。

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