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Identifying HIV care enrollees at-risk for cannabis use disorder

机译：鉴定大麻使用障碍风险的艾滋病毒护理登记

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Increased scientific attention given to cannabis in the United States has particular relevance for its domestic HIV care population, given that evidence exists for both cannabis as a therapeutic agent and cannabis use disorder (CUD) as a barrier to antiretroviral medication adherence. It is critical to identify relative risk for CUD among demographic subgroups of HIV patients, as this will inform detection and intervention efforts. A Center For AIDS Research Network of Integrated Clinical Systems cohort (N=10,652) of HIV-positive adults linked to care at seven United State sites was examined for this purpose. Based on a patient-report instrument with validated diagnostic threshold for CUD, the prevalence of recent cannabis use and corresponding conditional probabilities for CUD were calculated for the aggregate sample and demographic subgroups. Generalized estimating equations then tested models directly examining patient demographic indices as predictors of CUD, while controlling for history and geography. Conditional probability of CUD among cannabis-using patients was 49%, with the highest conditional probabilities among demographic subgroups of young adults and those with non-specified sexual orientation (67-69%) and the lowest conditional probability among females and those 50+ years of age (42% apiece). Similarly, youthful age and male gender emerged as robust multivariate model predictors of CUD. In the context of increasingly lenient policies for use of cannabis as a therapeutic agent for chronic conditions like HIV/AIDS, current study findings offer needed direction in terms of specifying targeted patient groups in HIV care on whom resources for enhanced surveillance and intervention efforts will be most impactful.
机译：在美国大麻的大麻提高了对其国内艾滋病毒护理人口的科学关注，鉴于大麻作为治疗剂和大麻用障碍（CUD）作为抗逆转录病毒药物依从性的障碍。鉴定HIV患者的人口统计亚组中CUD之间的相对风险至关重要，因为这将为检测和干预措施提供信息。为此目的，检查了艾滋病毒阳性成年人的综合临床系统综合体系综合成年人的艾滋病研究网络（n = 10,652），为此目的。基于患者报告仪器具有验证的CUD诊断阈值，为聚集样品和人口统计亚组计算了最近的大麻使用和相应条件概率的患病率。随后将模型直接检查患者人口统计指数作为CUD的预测因素，同时控制历史和地理位置。 Cud患者中的患者的概率为49％，其年轻成年人人口统计亚组的条件最高概率以及非特定性取向（67-69％）和女性的最低条件概率和50多年年龄（每组42％）。同样，年轻的年龄和男性性别被出现为CUD的鲁棒多元模型预测因子。在越来越宽松地使用大麻作为艾滋病毒/艾滋病等慢性条件的治疗剂的延续政策的背景下，目前的研究结果是提供所需的方向，以便在艾滋病毒护理中指定靶向患者群体，这些患者群体的资源加强监督和干预措施最有影响。

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