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首页> 外文期刊>AIDS care. >Trajectory of use over time of an oral tablet and a rectal gel for HIV prevention among transgender women and men who have sex with men
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Trajectory of use over time of an oral tablet and a rectal gel for HIV prevention among transgender women and men who have sex with men

机译：随着时间的推移，使用时间片剂和直肠凝胶，用于艾滋病毒预防艾滋病毒妇女和与男性发生性关系的男性

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We examined product adherence among 187 men who have sex with men and transgender women enrolled in a phase II, crossover trial comparing safety and acceptability of an oral tablet and a rectal gel used daily for HIV prevention. Participants reported adherence via daily text messages during 8-week periods. Trajectory analysis identified weekly patterns. Polytomous logistic regression identified characteristics associated with higher probability of trajectory group membership. We identified 3 groups per product: high-adherers (72% daily oral, 70% daily gel); decreasing-adherers (20% daily oral, 22% daily gel); and low-adherers (8% daily oral, 9% daily gel). Daily oral high-adherers (compared with low-adherers) were more likely to self-identify as male (OR = 4.76, 95% CI:1.35-16.67), to have more sexual partners (OR = 1.67, 95% CI:1.04-2.63), and to find the tablet easy to swallow (OR = 2.22, 95% CI:1.08-4.76). Daily gel high-adherers (compared with low-adherers) were more likely to be older (OR = 1.16, 95% CI:1.05-1.28), to find gel application easier at the last few applications (OR = 2.27, 95% CI:1.01-5.00), and to report a change in routine if gel was not used (OR = 5.26, 95% CI:1.23-100.00). Characteristics of participants likely to be high-adherers to product use vary according to product. Evaluation of acceptability prior to phase II/III trials could identify participants likely to maintain high adherence.
机译：我们在187名与男性和转型女性发生性关系的男性中检查了产品依从性，分叉试验比较了口腔片的安全性和可接受性和每日使用的直肠凝胶进行艾滋病毒预防。参与者在8周期间通过日常短信报告遵守。轨迹分析确定了每周模式。多元逻辑回归鉴定了与轨迹群成员较高概率相关的特征。我们确定了每种产品3组：高粘附（每日72％，每日70％凝胶）;减少 - 粘附（每日20％，每日22％凝胶）;和低粘附（每日8％的人，每日9％凝胶）。每日口腔高压剂（与低粘附者相比）更有可能自我识别，因为雄性（或= 4.76,95％CI：1.35-16.67），有更多的性伴侣（或= 1.67,95％CI：1.04 -2.63），并找到易吞咽的片剂（或= 2.22,95％CI：1.08-4.76）。每日凝胶高粘附者（与低粘附者相比）更容易较旧（或= 1.16,95％CI：1.05-1.28），在最近几个应用中找到凝胶应用程序（或= 2.27,95％CI ：1.01-5.00），报告常规的变化如果未使用凝胶（或= 5.26,95％CI：1.23-100.00）。参与者的特征可能是高粘附的产品使用根据产品而变化。在II / III期试验之前的可接受性评估可以识别可能保持高依从性的参与者。

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