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A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking

机译：艾滋病毒感染者具有危险饮酒史的遗传标记

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Impulsivity and sensation seeking have been linked to hazardous drinking, increased sexual risk behaviors, and lower treatment adherence among persons living with HIV (PLH). The dopamine active transporter1 (DAT1or SLC6A3) gene has been linked to impulsivity and sensation seeking in several populations but has not been investigated among populations of PLH. This study used data from 201 PLH who report a recent history of heavy episodic drinking. Results indicate that DAT1*10R vs DAT1*9R genotype was related to higher propensity for risk taking (standardized difference score (d)=0.30 [95% CI: 0.02;0.59]), more hazardous drinking (d=0.35 [0.05;0.64]), and more condomless sex (rate ratio (RR)=2.35[1.94; 2.85]), but were counter-intuitively associated with fewer sexual partners (RR=0.65[0.43;0.91]) and possibly better treatment adherence (d=0.32 [-0.01;0.65]). Results are consistent with the suggested associations between DAT1 and risk-taking behavior. The counter-intuitive finding for partner selection and treatment adherence may be evidence of additional factors that place PLH at risk for engaging in hazardous drinking as well as relationship difficulties and problems with treatment adherence (e.g., depressive symptoms, avoidant coping, trauma history). Caution is required when using a single gene variant as a marker of complex behaviors and these findings need to be replicated using larger samples and additional variants.
机译：冲动和感觉寻求与危险饮酒，增加性风险行为以及艾滋病毒（PLH）的人之间的治疗依赖性降低。多巴胺活性转运蛋白（DAT1OR SLC6A3）基因已与在几种群体中寻求的冲动和感觉相关，但尚未在PLH的群体中进行调查。本研究使用201 PLH的数据，他报告了最近的重型剧本饮酒历史。结果表明，DAT1 * 10R与DAT1 * 9R基因型与风险较高的倾向有关（标准化差异评分（D）= 0.30 [95％CI：0.02; 0.59]），更具危险的饮用（D = 0.35 [0.64] ]），更具通用性的性行为（率比（RR）= 2.35 [1.94; 2.85]），但与更少的性伴侣（RR = 0.65 [0.91]）和可能更好的治疗遵守（D = 0.32 [-0.01; 0.65]）。结果与DAT1之间的建议的协会符合，以及承担风险行为。伴侣选择和治疗依从性的反向直观的发现可能是将PLH放置危险饮酒的风险的额外因素以及治疗粘附的关系和问题（例如，抑郁症状，避免应对，创伤症状）。使用单个基因变体作为复杂行为的标记时，需要注意，并且需要使用较大的样品和其他变体来复制这些发现。

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