Extremely Severe CD4 Lymphopenia During HIV-1 Primary Infection

Bonnet Benjamin; Blum Laurent; Charpentier Charlotte; Martres Pascale; Ritvo Paul-Gydeon; Autran Brigitte; Guihot Amelie

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Extremely Severe CD4 Lymphopenia During HIV-1 Primary Infection

机译：HIV-1原发性感染期间极其严重的CD4淋巴结蛋白

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We report the case of a patient with a very profound CD4 T cell lymphopenia <20 cells/mm(3) in the context of a primary HIV-1 infection, associated with both delayed HIV-specific antibody and CD8 T cell responses. A long-term immune reconstitution was observed after immediate initiation of antiretroviral therapy.

机译：在初级HIV-1感染的情况下，用非常深入的CD4 T细胞淋巴结淋巴结<20细胞/ mm（3）举报患者的患者。与延迟的HIV特异性抗体和CD8 T细胞应答相关。立即开始抗逆转录病毒治疗后观察到长期免疫重建。

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来源
《AIDS Research and Human Retroviruses》 |2019年第10期|共4页
作者
Bonnet Benjamin; Blum Laurent; Charpentier Charlotte; Martres Pascale; Ritvo Paul-Gydeon; Autran Brigitte; Guihot Amelie;
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作者单位

Hop La Pitie Salpetriere AP HP Dept Immunol Paris France;

Ctr Hosp Rene Dubos Med Serv Pontoise France;

Univ Paris Diderot Hop Bichat AP HP Lab Virol Sorbonne Paris Cite IAME UMR 1137 INSERM Paris;

Ctr Hosp Rene Dubos Lab Microbiol Pontoise France;

INSERM U959 Paris France;

Hop La Pitie Salpetriere AP HP Dept Immunol Paris France;

Hop La Pitie Salpetriere AP HP Dept Immunol Paris France;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
HIV; CD4; immunosuppression; antibody; primary HIV infection; T cell;

机译：艾滋病毒;CD4;免疫抑制;抗体;初级HIV感染;T细胞;

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专利

1. Extremely Severe CD4 Lymphopenia During HIV-1 Primary Infection [J] . Bonnet Benjamin, Blum Laurent, Charpentier Charlotte, AIDS Research and Human Retroviruses . 2019,第10期

机译：HIV-1原发性感染期间极其严重的CD4淋巴结蛋白
2. Binding of HIV-1 virions to α₄β₇ expressing cells and impact of antagonizing α₄β₇ on HIV-1 infection of primary CD4+ T cells [J] . Chang, Li, Wei, 中国病毒学：英文版 . 2014,第006期

机译：HIV-1病毒体与表达α_{4 β_{7 的细胞的结合以及拮抗α_{4 β_{7 的影响HIV-1感染原代CD4 + T细胞}}}}
3. Atrophy of primary lymphoid organs induced by Marek’s disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia [J] . Camille Berthault, Thibaut Larcher, Sonja H?rtle, Veterinary research . 2018,第1期

机译：马立克氏病病毒在早期感染期间诱导的原发性淋巴器官萎缩与凋亡增加，细胞增殖抑制和严重的B淋巴细胞减少有关
4. Design of a CD4 miniprotein,powerful inhibitor of HIV-1 infection and potential potential component of an AIDS vaccine [C] . Loic Martin, Francois Stricher, Isabelle Freulon, European Peptide Symposium . 2002

机译：设计CD4微细蛋白，强大的HIV-1感染抑制剂及艾滋病疫苗的潜在潜在组分
5. Investigating the role of T cell activation on the establishment of HIV-1 latency in primary CD4+ T cells using a dual-reporter virus [D] . Chavez, Leonard 2014

机译：使用双报告病毒研究T细胞激活对原发性CD4 + T细胞HIV-1等待时间建立的作用
6. Contribution of immunological and virological factors to extremely severe primary HIV-1 infection [O] . Judith Dalmau, Maria Carmen Puertas, Marta Azuara, -1

机译：免疫和病毒学因素对极重度原发性HIV-1感染的贡献
7. First Report of CD4 Lymphopenia and Defective Neutrophil Functions in a Patient with Amebiasis Associated with CMV Reactivation and Severe Bacterial and Fungal Infections [O] . Ghrenassia, Etienne, Guihot, Amelie, Dong, Yuan, 2017

机译：CD4淋巴细胞减少症和嗜中性粒细胞功能缺陷的首次报道在患有CMV活化和严重细菌和真菌感染的氨苄虫病患者中

Extremely Severe CD4 Lymphopenia During HIV-1 Primary Infection

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