Characterization of HIV-1 Subtypes Among South Sudanese Patients

Lo Presti Alessandra; Farcomeni Stefania; Sulekova Lucia Fontanelli; Grieco Stefania; Sernicola Leonardo; Baesso Michela; Maggiorella Maria T.; Angeletti Silvia; Foley Brian; Ciccozzi Massimo; Taliani Gloria; Borsetti Alessandra

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Characterization of HIV-1 Subtypes Among South Sudanese Patients

机译：南苏丹患者HIV-1亚型的特征

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There is scarce data on circulation of genetic subtypes of HIV-1 in South Sudan due to decades of civil war. In this study, phylogenetic analysis of 10 strains collected from HIV-1-infected South Sudanese patients was performed. Partial pol and env viral gene analysis classified sequences as subtype C (n = 4), subtype D (n = 4), and partially unclassifiable recombinants (n = 2), interspersed within the phylogenetic tree with those from other African countries. These results indicate an exchange of viral strains between South Sudan and both neighboring and distant territories. The movements of populations across Sudan's borders during the civil war have probably played an important role in circulation of subtypes not only in South Sudan but also in other African states.

机译：由于多十年的内战，南苏丹遗传亚型遗传亚型循环数据存在稀缺数据。在这项研究中，进行了从HIV-1感染南苏丹患者收集的10个菌株的系统发育分析。部分POL和ENV病毒基因分析分类序列作为亚型C（n = 4），亚型d（n = 4），部分不可分配的重组剂（n = 2），与来自其他非洲国家的系统内散布在系统发育树内。这些结果表明南苏丹与邻近和遥远的地区之间的病毒株交换。在内战期间，苏丹边界的人口的运动可能在不仅在南苏丹的亚型，而且在其他非洲国家的亚型中发挥了重要作用。

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来源
《AIDS Research and Human Retroviruses》 |2019年第10期|共4页
作者
Lo Presti Alessandra; Farcomeni Stefania; Sulekova Lucia Fontanelli; Grieco Stefania; Sernicola Leonardo; Baesso Michela; Maggiorella Maria T.; Angeletti Silvia; Foley Brian; Ciccozzi Massimo; Taliani Gloria; Borsetti Alessandra;
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作者单位

Ist Super Sanita Dept Infect Dis Rome Italy;

Ist Super Sanita Natl HIV AIDS Res Ctr Vle Regina Elena 299 I-00161 Rome Italy;

Sapienza Univ Rome Dept Publ Hlth &

Infect Dis Infect Dis Unit Rome Italy;

Sapienza Univ Rome Dept Publ Hlth &

Infect Dis Infect Dis Unit Rome Italy;

Ist Super Sanita Natl HIV AIDS Res Ctr Vle Regina Elena 299 I-00161 Rome Italy;

Ist Super Sanita Natl HIV AIDS Res Ctr Vle Regina Elena 299 I-00161 Rome Italy;

Ist Super Sanita Natl HIV AIDS Res Ctr Vle Regina Elena 299 I-00161 Rome Italy;

Univ Campus Biomed Rome Dept Med Unit Clin Lab Sci Rome Italy;

Los Alamos Natl Lab Theoret Biol &

Biophys Grp Los Alamos NM USA;

Univ Campus Biomed Rome Dept Med Unit Clin Lab Sci Rome Italy;

Sapienza Univ Rome Dept Publ Hlth &

Infect Dis Infect Dis Unit Rome Italy;

Ist Super Sanita Natl HIV AIDS Res Ctr Vle Regina Elena 299 I-00161 Rome Italy;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
HIV; diversity; dried blood spot; South Sudan; Africa;

机译：艾滋病毒;多样性;干血斑;南苏丹;非洲;

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专利

1. Characterization of HIV-1 Subtypes Among South Sudanese Patients [J] . Lo Presti Alessandra, Farcomeni Stefania, Sulekova Lucia Fontanelli, AIDS Research and Human Retroviruses . 2019,第10期

机译：南苏丹患者HIV-1亚型的特征
2. Phylogenetic characterization of six full-length HIV-1 subtype C molecular clones from three patients: Identification of rare subtype C strains containing two NF-κB motifs in the long terminal repeat [J] . HannaL.E., NeogiU., RangaU., AIDS Research and Human Retroviruses . 2014,第6期

机译：来自三位患者的六个全长HIV-1 C型亚型分子克隆的系统发生特征：鉴定出在长末端重复序列中包含两个NF-κB图案的罕见C型亚型菌株
3. Molecular Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 in Yaoundé, Cameroon: Evidence of Major Drug Resistance Mutations in Newly Diagnosed Patients Infected with Subtypes Other than Subtype B [J] . Nicaise Ndembi, Awet Abraha, Heather Pilch, Journal of Clinical Microbiology . 2008,第1期

机译：喀麦隆雅温得的人类免疫缺陷病毒1型（HIV-1）和HIV-2的分子特征：在新诊断的感染了B型以外的患者中，主要耐药突变的证据
4. Coreceptor Utilization of HIV-1 Subtype C Viruses from the Limpopo Province of South Africa [C] . P.O. Bessong, M. Phoswa, T. Cilliers International AIDS Conference . 2004

机译：来自南非湖泊省的HIV-1亚型C病毒的团簇利用
5. Characterization of new HIV-1 sub-subtype in West Africa: HIV-1 A3. [D] . Meloni, Seema Thakore. 2005

机译：西非新的HIV-1亚型的特征：HIV-1 A3。
6. Molecular Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 in Yaoundé Cameroon: Evidence of Major Drug Resistance Mutations in Newly Diagnosed Patients Infected with Subtypes Other than Subtype B [O] . Nicaise Ndembi, Awet Abraha, Heather Pilch, 2008

机译：喀麦隆雅温得的人类免疫缺陷病毒1型（HIV-1）和HIV-2的分子特征：在新诊断的感染了B型以外的患者中主要耐药性突变的证据
7. Molecular Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 in Yaoundé, Cameroon: Evidence of Major Drug Resistance Mutations in Newly Diagnosed Patients Infected with Subtypes Other than Subtype B▿ [O] . Ndembi, Nicaise, Abraha, Awet, Pilch, Heather, 2007

机译：喀麦隆雅温得的人类免疫缺陷病毒1型（HIV-1）和HIV-2的分子特征：在新诊断的B型以外的患者中，主要耐药突变的证据

Characterization of HIV-1 Subtypes Among South Sudanese Patients

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