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首页> 外文期刊>AIDS Research and Human Retroviruses >Short Communication: HIV Patient Systemic Mitochondrial Respiration Improves with Exercise
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Short Communication: HIV Patient Systemic Mitochondrial Respiration Improves with Exercise

机译：短期通信：HIV患者全身线粒体呼吸改善了运动

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摘要

In HIV-infected individuals, impaired mitochondrial function may contribute to cardiometabolic disease as well as to fatigue and frailty. Aerobic exercise improves total body energy reserves; however, its impact at the cellular level is unknown. We assessed alterations in cellular bioenergetics in peripheral blood mononuclear cells (PBMC) before and after a 12-week aerobic exercise study in sedentary HIV-infected subjects on stable antiretroviral therapy who successfully completed a 12-week aerobic exercise program. In this prospective study, participants underwent supervised 20-40min of light aerobic exercise (walking or jogging) performed three times per week for 12 weeks, gradually increasing to maintain an intensity of 50%-80% of heart rate reserve. Maximal aerobic capacity (VO2MAX) was assessed by a graded exercise test on a cycle ergometer before and after completion of the study. PBMC from compliant subjects (attended at least 70% of exercise sessions) were assessed for mitochondrial respiration using the Seahorse XF24 Bio-Analyzer. Seven of 24 enrolled subjects were compliant with the exercise regimen. In these individuals, a significant increase (p=.04) in VO2MAX over 12 weeks was found with a median increase of 14%. During the same interval, a 2.45-fold increase in PBMC mitochondrial respiratory capacity (p=.04), a 5.65-fold increase in spare respiratory capacity (p=.01), and a 3.15-fold (p=.04) increase in nonmitochondrial respiration was observed. Aerobic exercise improves respiration at the cellular level. The diagnostic and prognostic value of such improved cellular respiration in the setting of chronic HIV warrants further investigation.
机译：在艾滋病毒感染的个体中，受损的线粒体功能可能有助于心细镜疾病以及疲劳和脆弱。有氧运动可提高全身能量储备;然而，它在细胞层面的影响是未知的。在稳定的艾滋病毒感染受试者的稳定抗逆转录病毒治疗中，在12周的有氧运动研究之前和之后评估了外周血单核细胞（PBMC）细胞生物能量学中的改变。在这项前瞻性研究中，参与者接受了每周三次的3次4次监督20-40分钟，持续12周，逐渐增加，以维持心率储备的50％-80％的强度。在研究完成之前和之后，通过对循环测量计进行评分运动试验来评估最大好氧能力（VO2MAX）。使用Seahorse XF24 Bio-Analyzer评估来自柔顺科目的PBMC（参加了至少70％的运动会话），对线粒体呼吸评估了线粒体呼吸。 24个注册科目中的七个符合锻炼方案。在这些个体中，发现vo2max的大幅增加（p = 0.04）超过12周，中位数增加14％。在相同的间隔期间，PBMC线粒体呼吸能力（P = 0.04）增加2.45倍，备用呼吸能力增加5.65倍（P = .01），增加3.15倍（P = .04）增加观察到非渗透镜呼吸。有氧运动改善了细胞水平的呼吸。这种改善的细胞呼吸在慢性艾滋病毒艾滋病毒的诊断和预后价值进一步调查。

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    Kocher Morgan; McDermott Mindy; Lindsey Rachel; Shikuma Cecilia M.; Gerschenson Mariana; Chow Dominic C.; Kohorn Lindsay B.; Hetzler Ronald K.; Kimura Iris F.;

  • 作者单位

    Univ Hawaii Manoa Dept Kinesiol &

    Rehabil Sci Coll Educ 651 Ilalo St Suite 231 Honolulu HI;

    Univ Hawaii Manoa John A Burns Sch Med Dept Cell &

    Mol Biol 651 Ilalo St Suite 231 Honolulu HI;

    Univ Hawaii Manoa Dept Kinesiol &

    Rehabil Sci Coll Educ 651 Ilalo St Suite 231 Honolulu HI;

    Univ Hawaii Manoa John A Burns Sch Med Dept Med Hawaii Ctr AIDS 651 Ilalo St Suite 231;

    Univ Hawaii Manoa John A Burns Sch Med Dept Cell &

    Mol Biol 651 Ilalo St Suite 231 Honolulu HI;

    Univ Hawaii Manoa John A Burns Sch Med Dept Med Hawaii Ctr AIDS 651 Ilalo St Suite 231;

    Univ Hawaii Manoa John A Burns Sch Med Dept Cell &

    Mol Biol 651 Ilalo St Suite 231 Honolulu HI;

    Univ Hawaii Manoa Dept Kinesiol &

    Rehabil Sci Coll Educ 651 Ilalo St Suite 231 Honolulu HI;

    Univ Hawaii Manoa Dept Kinesiol &

    Rehabil Sci Coll Educ 651 Ilalo St Suite 231 Honolulu HI;

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  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    aerobic; cardiovascular fitness; VO2MAX;

    机译：有氧运动;心血管健身;vo2max;

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