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首页> 外文期刊>AIDS Research and Human Retroviruses >Early Sites of Virus Replication After Oral SIV mac251 Infection of Infant Macaques: Implications for Pathogenesis
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Early Sites of Virus Replication After Oral SIV mac251 Infection of Infant Macaques: Implications for Pathogenesis

机译：病毒复制早期位点，在口服SIV MAC251感染婴儿猕猴：对发病机制的影响

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Despite optimization of preventative measures for vertical HIV-1 transmission, daily, roughly 400 infants become HIV infected, most of them through breastfeeding. Viral entry has been presumed to occur in the gastrointestinal tract; however, the exact entry site(s) have not been defined. Therefore, we quantified simian immunodeficiency virus (SIV) RNA and DNA in oral, intestinal, and systemic tissues of 15 infant macaques within 48–96 h after oral SIV_(mac251) exposure. SIV DNA was detected as early as 48 h, whereas SIV RNA was typically detected at later time points (72–96 h). Transmitted founder viruses were identical or very similar to a single genotype in the SIV_(mac251) challenge stock. SIV RNA and DNA were most frequently found in lymph nodes (LNs) draining the oral cavity and in the ileum. Using in situ hybridization, SIV-infected cells in LNs were exclusively represented by CD3~(+) T cells. SIV RNA and DNA were also detected in the lungs of 20% of the animals, and 60% of the animals had detectable SIV DNA in the cerebrum. The early detection of viral RNA or DNA in lung and brain tissues emphasizes the need for early treatment of pediatric HIV infection to prevent damage not only to the immune system but also to the respiratory tract and central nervous system.
机译：尽管优化了垂直HIV-1传输的预防性措施，但每天，大约400名婴儿被艾滋病毒感染，其中大多数通过母乳喂养。病毒进入已被推测发生在胃肠道中;但是，尚未定义确切的入口站点。因此，在口服SIV_（MAC251）暴露后，我们在口服，肠道和系统组织中量化了猿猴免疫缺陷病毒（SIV）RNA和DNA，在48-96小时内，在48-96小时内在48-96小时内。早在48小时检测到SIV DNA，而在稍后的时间点（72-96小时）通常检测到SIV RNA。透过的创始者病毒与SIV_（MAC251）挑战股中的单一基因型相同或非常相似。淋巴结（LNS）中最常发现SIV RNA和DNA，排出口腔和回肠。使用原位杂交，LNS中的SIV感染细胞仅由CD3〜（+）T细胞表示。在20％的动物的肺部中也检测到SIV RNA和DNA，并且60％的动物在大脑中有可检测的SIV DNA。肺癌和脑组织中病毒RNA或DNA的早期检测强调需要早期治疗儿科艾滋病毒感染，以防止损伤不仅对免疫系统而且还对呼吸道和中枢神经系统的损伤。

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