Low Frequency of Protease Inhibitor Resistance Mutations and Insertions in HIV-1 Subtype C Protease Inhibitor-Naive Sequences

Ledwaba Johanna; Sayed Yasien; Pillay Visva; Morris Lynn; Hunt Gillian

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Low Frequency of Protease Inhibitor Resistance Mutations and Insertions in HIV-1 Subtype C Protease Inhibitor-Naive Sequences

机译：低频率的蛋白酶抑制剂抗突变和HIV-1亚型C蛋白酶抑制剂 - 野序列的插入

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Human immunodeficiency virus-1 (HIV-1) protease sequences from 2,225 protease inhibitor (PI)-naive HIV-1 subtype C-infected individuals collected over a 14-year period were analyzed for polymorphisms. Over 50% of sequences differed from an HIV-1 subtype B consensus sequence at 8 of the 99 amino acids at residues 12, 15, 19, 36, 41, 69, 89, and 93, but not in the functionally important regions. The frequency of primary resistance and accessory mutations occurred in <1% of the sequences. Of note, 11 sequences (0.5%) harbored amino acid insertions between residues 36 and 39, located in the elbow of the flap region. The insertions were found throughout the 13-year period. Occurrence of insertions in subtype C viruses is rare and viruses remain sensitive to currently used PIs (lopinavir/r, atazanavir/r, and darunavir/r). However, ongoing characterization of isolates is required to identify changes that may impact PI treatment since PIs are part of standard SA regimens.

机译：分析了2,225蛋白酶抑制剂（PI）的人免疫缺陷病毒-1（HIV-1）蛋白酶序列 - 用于多态性，在14年期间收集的HIV-1亚型C感染个体。在残基12,15,19,36,41,69,89和93的99个氨基酸的8个中，在99个氨基酸中的8个中，在HIV-1亚型B的共分序列中不同的50％序列不同，但不在功能重要的区域中。初级电阻和附带突变的频率发生在<1％的序列中。值得注意的是，位于翼片区域的弯头中的残基36和39之间的11个序列（0.5％）存在残留物36和39之间的氨基酸插入。在整个13年期间发现了插入。亚型C病毒插入的发生是罕见的，病毒对目前使用的PIS（Lopinavir / R，Atazanavir / R和Darunavir / R）仍然敏感。然而，由于PI是标准SA方案的一部分，因此需要对分离物的持续表征鉴定可能影响PI治疗的变化。

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来源
《AIDS Research and Human Retroviruses》 |2019年第7期|共6页
作者
Ledwaba Johanna; Sayed Yasien; Pillay Visva; Morris Lynn; Hunt Gillian;
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作者单位

Natl Inst Communicable Dis Ctr HIV &

STIs Johannesburg South Africa;

Univ Witwatersrand Sch Mol &

Cell Biol Prot Struct Funct Res Unit Johannesburg South Africa;

Natl Inst Communicable Dis Ctr HIV &

STIs Johannesburg South Africa;

Natl Inst Communicable Dis Ctr HIV &

STIs Johannesburg South Africa;

Natl Inst Communicable Dis Ctr HIV &

STIs Johannesburg South Africa;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
HIV-1; insertions; mutations; polymorphisms; subtype C; protease;

机译：HIV-1;插入;突变;多态性;亚型C;蛋白酶;

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1. Low Frequency of Protease Inhibitor Resistance Mutations and Insertions in HIV-1 Subtype C Protease Inhibitor-Naive Sequences [J] . Ledwaba Johanna, Sayed Yasien, Pillay Visva, AIDS Research and Human Retroviruses . 2019,第7期

机译：低频率的蛋白酶抑制剂抗突变和HIV-1亚型C蛋白酶抑制剂 - 野序列的插入
2. SUSTAINED APPEARANCE OF DRUG RESISTANCE-ASSOCIATED MUTATIONS IN HIV-1 CRF01_AE PROTEASE AND REVERSE TRANSCRIPTASE DERIVED FROM PROTEASE INHIBITOR-NAIVE THAI PATIENTS [J] . Duangrat Jullaksorn, Samatchaya Boonchawalit, Jiraporn Uttiyoung, The Southeast Asian journal of tropical medicine and public health . 2010,第2期

机译：HIV-1 CRF01_AE蛋白酶耐药性突变的持续表现以及来自蛋白酶原初泰国患者的逆转录酶
3. The frequencies of naturally occurring protease inhibitor resistance mutations in HIV proviral sequences of drug na?ve sex workers in Nairobi, Kenya and their correlation with host immune response driven positively selected mutations in HIV-1 [J] . Raghavan Sampathkumar, Elnaz Shadabi, David La, BMC Infectious Diseases . 2014,第SUPPLEMENTa3期

机译：肯尼亚内罗毕单纯毒品性工作者艾滋病毒前病毒序列中天然存在的蛋白酶抑制剂抗药性突变的频率及其与宿主免疫反应的相关性，驱动HIV-1的阳性选择突变
4. Computational Mutation Scanning and Drug Resistance Mechanisms of HIV-1 Protease Inhibitors [C] . Ge-Fei Hao, Guang-Fu Yang, Chang-Guo Zhan ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：HIV-1蛋白酶抑制剂的计算突变扫描和耐药机制
5. Design and synthesis of core structural intermediates for novel HIV-1 protease inhibitors and synthesis, biological activity and molecular modeling of novel 20S proteasome inhibitors. [D] . Avancha, Kiran Kumar Venkata Raja. 2006

机译：新型HIV-1蛋白酶抑制剂的核心结构中间体的设计与合成，新型20S蛋白酶体抑制剂的合成，生物学活性和分子建模。
6. The frequencies of naturally occurring protease inhibitor resistance mutations in HIV proviral sequences of drug naïve sex workers in Nairobi Kenya and their correlation with host immune response driven positively selected mutations in HIV-1 [O] . Raghavan Sampathkumar, Elnaz Shadabi, David La, 2014

机译：肯尼亚内罗毕无毒品性工作者艾滋病前病毒序列中天然蛋白酶抑制剂抗性突变的频率及其与宿主免疫反应的相关性驱动HIV-1的阳性选择突变
7. The frequencies of naturally occurring protease inhibitor resistance mutations in HIV proviral sequences of drug naïve sex workers in Nairobi, Kenya and their correlation with host immune response driven positively selected mutations in HIV-1 [O] . Raghavan Sampathkumar, Elnaz Shadabi, David La, 2014

机译：肯尼亚内罗毕无毒品性工作者艾滋病前病毒序列中天然蛋白酶抑制剂抗性突变的频率及其与宿主免疫反应的相关性，驱动HIV-1的阳性选择突变

Low Frequency of Protease Inhibitor Resistance Mutations and Insertions in HIV-1 Subtype C Protease Inhibitor-Naive Sequences

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