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首页> 外文期刊>Alcohol >Intermittent voluntary ethanol consumption combined with ethanol vapor exposure during adolescence increases drinking and alters other behaviors in adulthood in female and male rats
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Intermittent voluntary ethanol consumption combined with ethanol vapor exposure during adolescence increases drinking and alters other behaviors in adulthood in female and male rats

机译：间歇自愿乙醇消耗结合青春期期间乙醇蒸气暴露量增加饮酒，改变成年性雌性和雄性大鼠的其他行为

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Epidemiological studies suggest that binge drinking is prevalent among adolescents, and may result in neurobehavioral consequences. Animal models provide the experimental control to investigate the consequences of "binge" alcohol exposure during this neurodevelopmental epoch. The current study used an animal model that combined an intermittent pattern of alcohol vapor exposure with voluntary drinking of 20% unsweetened alcohol in adolescent male and female Wistar rats (postnatal day IRA 22 -62), in order to test for potential differences in behavioral changes, ethanol drinking, and hypocretin/orexin (Hcrt/OX) signaling associated with exposure status. Two weeks after discontinuation of the alcohol vapor exposure and drinking during adolescence, rats were tested in adulthood for anxiety-like behaviors using a modified open-field conflict task, pre-pulse facilitation of startle response, light/dark box, and marble burying test. Adolescent alcohol exposure led to overall decreased startle response and increased behavioral arousal in the light/dark chamber during adulthood. Additionally, male rats demonstrated more disinhibited behavior during the conflict task compared to females, and female rats exhibited more rearing behavior during the light/dark test. Rats were also given a 2-bottle choice test that resulted in adolescent alcohol-exposed rats drinking significantly more alcohol in adulthood. Further, female rats also consumed more alcohol in adulthood compared to males. Estrous cycle phase did not account for any of the sex differences observed in the behavioral measures. Histological results indicated that adolescent alcohol did not alter Hcrt/OX-1 or Hcrt/OX-2 receptor mRNA expression levels in adult rats compared to control adults. However, female rats expressed a higher level of Hcrt/OX-1 and Hcrt/OX-2 receptor mRNA in the frontal cortex compared to males. These data suggest that our current model of intermittent ethanol exposure in adolescence can modestly affect both behavior and future consumption of alcohol and that Hcrt/OX receptor signaling differs between males and females. (C) 2018 Elsevier Inc. All rights reserved.
机译：流行病学研究表明，青少年的狂欢饮酒是普遍的，可能导致神经麻烦后果。动物模型提供了实验对照，探讨了这种神经开发时期的“狂欢”酒精暴露的后果。目前的研究用来了一种动物模型，将醇蒸气暴露的间歇模式组合在青少年雄性和女性Wistar大鼠（产后日IRA 22 -62）中具有20％不含糖的自愿饮用，以测试行为变化​​的潜在差异，乙醇饮用，以及与暴露状态相关的信令信号传导。在白光停止酒精蒸气暴露和饮用后两周，使用修改的开放式冲突任务，令人震惊的开放式冲突任务，令人震惊的响应，浅色/暗盒和大理石埋葬测试，在成年为焦虑的行为进行大鼠。 。青少年酒精曝光导致在成年期间，在光/暗室中总体下降和增加行为唤醒。另外，与女性相比，雄性大鼠在冲突任务期间表现出更令人失望的行为，并且在光/暗试验期间雌性大鼠表现出更多的饲养行为。还给出了2瓶选择试验，导致青少年酒精暴露的大鼠在成年期饮用的饮酒明显。此外，与男性相比，雌性大鼠在成年期间也会在成年中消耗更多的酒精。在行为措施中观察到的任何性别差异，不陈述的发言循环阶段。组织学结果表明，与对照成人相比，青少年醇未改变成年大鼠的HCRT / Ox-1或HCRT / OX-2受体mRNA表达水平。然而，与雄性相比，雌性大鼠在额叶中表达了额前皮质中的HCRT / OX-1和HCRT / OX-2受体mRNA。这些数据表明，我们在青春期间歇性乙醇暴露的目前模型可以谦虚地影响醇的行为和未来消耗，并且HCRT /牛受体信号传导在雄性和女性之间不同。 （c）2018年Elsevier Inc.保留所有权利。

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