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Mortality and costs associated with alcoholic hepatitis: A claims analysis of a commercially insured population

机译：与酒精性丙型肝炎相关的死亡率和成本：商业上有人的索赔分析

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摘要

Rising mortality in the United States due to alcoholic liver disease (ALD) and the dearth of effective treatments for ALD have led to increased research in this area, particularly in alcoholic hepatitis. To understand the burden of illness and potential economic value of effective treatments, we conducted a health care claims analysis of over 15,000 commercially insured adults who were hospitalized with alcoholic hepatitis (AH) between 2006 and 2013 and followed for up to 5 years. Their average age was 54 years and 68% were male. Over 5 years, about two-thirds of these adults died (44% in the first year), and fewer than 500 received liver transplants. There were nearly 40,000 re-hospitalizations, with over 50% of the survivors re-hospitalized within a year and nearly 75% through the second year. The total costs were nearly $145,000 per patient, with costs decreasing over time from over $50,000 in the first year (including the index hospitalization) to about $10,000 per year in the later years. Total costs for the cohort over 5 years were $2.2 billion. Patients who received a liver transplant averaged about $300,000 in transplant-related costs and over $1,000,000 in total health care costs over 5 years. Average costs in years following the index hospitalization were similar to diabetes. AH has a high mortality and is a high-cost condition.
机译：由于酒精性肝病（ALD）和对ALD的有效治疗的缺乏，美国的死亡率上升导致该地区的研究增加，特别是在酒精性肝炎中。要了解有效治疗的疾病负担和潜在的经济价值，我们对2006年至2013年间的含有酒精性丙型肝炎（AH）住院的15,000多人的医疗保健声明分析，并随后长达5年。他们的平均年龄为54岁，68％是男性。超过5年，约有三分之二的成年人死亡（第一年44％），少于500名接受肝脏移植。近40,000名重新住院，50％以上的幸存者在一年内重新住院，近75％到第二年。每位患者的总费用近145,000美元，随着时间的推移，成本从超过50,000美元下降（包括指数住院）在后期每年约10,000美元。队列超过5年的总费用为22亿美元。接受肝脏移植的患者在移植相关成本中平均约为300,000美元，并且在5年内卫生保健总费用超过1,000,000美元。指数住院后的年度平均成本与糖尿病相似。啊死亡率很高，是一种高成本的条件。

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