Associations between gastrointestinal humoral factors and pancreatic proteolytic enzymes in alcohol-related versus non-alcohol-related pancreatitis

Bharmal Sakina H.; Pendharkar Sayali A.; Singh Ruma G.; Petrov Maxim S.

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Associations between gastrointestinal humoral factors and pancreatic proteolytic enzymes in alcohol-related versus non-alcohol-related pancreatitis

机译：胃肠道体液因子与胰腺蛋白水解酶与含醇相关的胰腺相关性与非酒精相关的胰腺炎之间的关联

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Background: Alcohol-related pancreatitis is common and the gastrointestinal tract plays an important role in the regulation of pancreatic exocrine function. While the relationship between pancreatic proteolytic enzymes and insulin (as well as other pancreatic hormones) has been investigated in detail, little is known about the relationship between pancreatic proteolytic enzymes and gastrointestinal humoral factors. The aim of this study was to study the associations between trypsin, chymotrypsin, and a panel of gastrointestinal humoral factors in patients after an episode of alcohol-related versus non-alcohol related pancreatitis.

机译：背景：含有酒精相关的胰腺炎是常见的，胃肠道在胰腺外分泌功能的调节中起着重要作用。虽然已经详细研究了胰腺蛋白水解酶和胰岛素（以及其他胰腺）之间的关系，但关于胰腺蛋白水解酶和胃肠道体液因子之间的关系很少。本研究的目的是研究胰蛋白酶，胰凝乳蛋白酶和患者的胃肠体液因子与非酒精相关胰腺炎的一集后患者胃肠体液因子之间的关联。

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来源
《Alcohol》 |2019年第2019期|共10页
作者
Bharmal Sakina H.; Pendharkar Sayali A.; Singh Ruma G.; Petrov Maxim S.;
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作者单位

Univ Auckland Sch Med Auckland New Zealand;

Univ Auckland Sch Med Auckland New Zealand;

Univ Auckland Sch Med Auckland New Zealand;

Univ Auckland Sch Med Auckland New Zealand;

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原文格式 PDF
正文语种 eng
中图分类中毒及化学性损害;
关键词
Trypsin; Chymotrypsin; Alcohol-related pancreatitis; Gut hormones; Pancreas;

机译：胰蛋白酶;chymotrypsin;酒精相关的胰腺炎;肠道荷尔蒙;胰腺;

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1. Associations between gastrointestinal humoral factors and pancreatic proteolytic enzymes in alcohol-related versus non-alcohol-related pancreatitis [J] . Bharmal Sakina H., Pendharkar Sayali A., Singh Ruma G., Alcohol . 2019,第期

机译：胃肠道体液因子与胰腺蛋白水解酶与含醇相关的胰腺相关性与非酒精相关的胰腺炎之间的关联
2. The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormoneseurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules [J] . SanchoV., Nuche-BerenguerB., JensenR.T. Biochimica et biophysica acta. Molecular cell research . 2012,第8期

机译：Src激酶Yes在胃肠腺细胞中被胃肠道激素/神经递质激活，但未被胰腺生长因子激活，从而刺激其与众多其他信号分子的缔合
3. International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club [J] . David C. Whitcomb, Tooru Shimosegawa, Suresh T. Chari, Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] . 2018,第5期

机译：国际慢性慢性胰腺炎的共识陈述。与国际胰腺协会，美国胰腺协会，日本胰腺协会，胰腺胰腺组合，胰腺活灭工作组和欧洲胰俱乐部合作，慢性胰腺炎工作组工作组的建议
4. Truncation of CXCL12, Stromal Cell Derived Factor-1, by Proteolytic Enzymes in Bone Marrow from Patients with Polycythemia Vera [C] . Sool Yeon Cho, Mingjiang Xu, John Roboz, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：来自多胆症Vera患者的骨髓中的蛋白水解酶截短CXCL12，基质细胞衍生因子-1
5. Factors influencing the early results of pancreatic islet transplantation: Studies on isolation enzymes and islet revascularisation - Summary. [D] . Mathe, Zoltan. 2007

机译：影响胰岛移植早期结果的因素：分离酶和胰岛血运重建的研究-摘要。
6. Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. [O] . C Niederau, R A Liddle, L D Ferrell, 1986

机译：在小鼠实验性急性出血性胰腺炎中胆囊收缩素受体阻滞的有益作用和蛋白水解酶活性的抑制。胆囊收缩素是急性胰腺炎发展的主要因素的证据。
7. Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. [O] . Niederau, C, Liddle, R A, Ferrell, L D, 1986

机译：在小鼠实验性急性出血性胰腺炎中，胆囊收缩素受体阻滞的有益作用和蛋白水解酶活性的抑制。胆囊收缩素是急性胰腺炎发展的主要因素的证据。

Associations between gastrointestinal humoral factors and pancreatic proteolytic enzymes in alcohol-related versus non-alcohol-related pancreatitis

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