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首页> 外文期刊>Alcohol >Forced ethanol ingestion by Wistar rats from a juvenile age increased voluntary alcohol consumption in adulthood, with the involvement of orexin-A
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Forced ethanol ingestion by Wistar rats from a juvenile age increased voluntary alcohol consumption in adulthood, with the involvement of orexin-A

机译：来自青少年年龄的Wistar大鼠摄取的强迫乙醇摄入成年人的自愿酒精消耗，orexin-a的参与

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Human adolescents who drink alcohol are more likely to become alcoholics in adulthood. Alcohol administration (intraperitoneally) or drinking (in a 2-bottle free choice paradigm) during the juvenile/adolescent age of rats promotes voluntary alcohol consumption in adulthood. On the other hand, there is growing evidence that the orexinergic system plays a role in several rewarded behaviors, including alcohol ingestion. Since it is unknown what effect is exerted in adulthood by forced oral ethanol intake and/or administration of orexin-A (OX-A) in juvenile rats, the present study aimed to evaluate this question. A group of male Wistar rats was forced to drink ethanol (10% v/v) as the only liquid in the diet from weaning (postnatal day 21) to postnatal day 67 (46 days), followed by a forced withdrawal period. An age-matched group was raised drinking tap water (control). OX-A or its vehicle was microinjected intracerebroventricularly (i.c.v.) (1?nmol/0.6?μL) to explore its effect as well. Locomotor activity and voluntary ethanol consumption were later assessed in all groups. The rats forced to consume ethanol early in life showed an elevated level of ambulation and alcohol ingestion in adulthood. A single injection of OX-A increased locomotor activity and acute ethanol intake in rats with or without prior exposure to alcohol at the juvenile stage. In conclusion, forced ethanol consumption in juvenile rats led to increased voluntary alcohol drinking behavior during adulthood, an effect likely facilitated by OX-A.
机译：喝酒的人青少年更有可能成为成年人的酗酒者。酒精管理（腹膜内）或饮用于大鼠青少年/青少年时代的少年/青少年期间饮用（在2瓶免费选择范式中）促进了成年期的自愿饮酒。另一方面，越来越多的证据表明，纠正了纠正的制度在几种奖励行为中起着作用，包括酒精摄取。由于尚不清楚的是，通过强制性的口服乙醇摄入和/或施用少年大鼠的orexin-a（Ox-a），所以目前的研究旨在评估这个问题。将一组男性Wistar大鼠被迫饮用乙醇（10％v / v），作为饮食中唯一的饮食中的饮食中的唯一液体（第21天）至第67天（46天），然后是强迫戒断期。年龄匹配的团体升高饮用自来水（对照）。 Ox-A或其载体是微内注射的脑内（I.C.V.）（1？Nmol / 0.6×μl），探讨其效果。在所有群体中，后来评估了机车活动和自愿乙醇消费。迫使乙醇早期消耗乙醇的大鼠在成年期显示出升高的气管和酒精摄入水平。单一注射OX-A增加的运动活性和急性乙醇在少年阶段在少年前暴露于醇的大鼠。总之，少年大鼠的强迫乙醇消耗导致成年期间增加自愿酒精饮酒行为，牛-A可能促进的效果。

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