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首页> 外文期刊>Alcohol >Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine D 3 receptors
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Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine D 3 receptors

机译：在恒河猴乙醇中引发了静脉乙醇，经验自我管理可卡因和乙醇：多巴胺D 3受体的参与

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Characterization of the effects of long-term alcohol consumption on the brain would be aided by the development of behavioral assays that are relatively easy to implement in animal models of alcohol use disorders. Assessing unconditioned behaviors, such as drug-elicited yawning in models that permit long-term alcohol ingestion, may be a valuable complement to more invasive and costly procedures. The present studies investigated previous unexpected findings of ethanol-induced yawning in nonhuman primates. Subjects were adult male rhesus monkeys (n?=?8), all of which had experience self-administering intravenous cocaine for several years. Four monkeys also had experience consuming 2.0?g/kg ethanol over 1?h per day, 5 days per week, for 6.8–12.0 months. All monkeys received saline or ethanol (0.25–1.0?g/kg) infused intravenously (i.v.) over 10?min, and the number of yawns elicited during the infusion was counted. A second experiment in the ethanol-experienced monkeys examined whether ethanol-induced yawning could be blocked by PG01037 (1.0, 3.0?mg/kg, i.v.), a selective antagonist at dopamine D3receptors (D3R). Ethanol significantly and dose-dependently increased yawns in the ethanol-experienced animals, but not the ethanol-na?ve animals. In the ethanol-experienced monkeys, this effect of ethanol was blocked by the D3R antagonist. The pharmacology of yawning is complex and a good deal of model development remains to be performed to characterize the potential involvement of other neurotransmitter systems. Nonetheless, drug-elicited yawning may be a useful unconditioned behavioral assay to assess the effects of long-term alcohol consumption in established nonhuman primate models.
机译：通过在酒精使用障碍的动物模型中实施相对容易实施的行为测定，对大脑上长期醇消耗的影响的表征将得到促进。评估无条件的行为，例如允许长期酒精摄取的模型中的药物引发的打呵欠，可能是对更多侵入性和昂贵的程序的有价值的补充。本研究研究了在非人印象中乙醇诱导的乙醇诱导的乙醇诱导的发现。受试者是成年雄性恒河猴（N？=？8），所有这些都有几年来自我治疗静脉内可卡因。四只猴子也有2.0克/千克乙醇的经验每周5天，每周5天，6.8-12.0个月。所有猴子接受盐水或乙醇（0.25-1.0？g / kg）静脉注射（I.v.）超过10？分钟，并且计数在输注过程中引起的打击的次数。乙醇经验丰富的猴子中的第二种实验检查了乙醇诱导的偏航是否可以通过PG01037（1.0,3.0，3.0×mg / kg，I.v.），在多巴胺D3receptors（D3R）中的选择性拮抗剂。乙醇显着依赖于乙醇 - 经验丰富的动物中的突发，但不是乙醇-NA ve动物。在乙醇经验丰富的猴子中，D3R拮抗剂阻断了乙醇的这种效果。打呵欠的药理学是复杂的，并且仍有许多模型开发，以表征其他神经递质系统的潜在参与。尽管如此，药物引发的打呵欠可能是一个有用的无条件的行为测定，以评估长期醇消耗在既定的非洲灵长类动物模型中的影响。

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