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The impact of low to moderate chronic intermittent ethanol exposure on behavioral endpoints in aged, adult, and adolescent rats

机译：低于中度慢性间歇性乙醇暴露对年龄，成人和青春期大鼠行为终点的影响

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The average age of the population in the United States and other countries is increasing. Understanding the health consequences in the aged population is critical. Elderly individuals consume ethanol, often at elevated rates, and in some cases in a binge episode. The present study sought to investigate whether binge-like ethanol exposure in aged male rats produced differential health and behavioral effects compared to adult male and adolescent male rats. Subjects were exposed to either 1.0 g/kg or 2.0 g/kg ethanol every other day via intraperitoneal injection for 20 days, and tested on a variety of behavioral measures and body weight. Binge-like ethanol exposure produced differential effects on body weight between aged and adolescent and adult rats. In addition, aged rats had a significantly longer loss of righting reflex and demonstrated a trend toward tolerance following the 2.0-g/kg exposure. No significant effects on anxiety-like behavior as measured by open arm entries, depressive-like symptoms as measured by immobility in the forced swim test, or cognitive performance as measured by latency and path length in the Morris water maze were found. These results demonstrate that aged animals are differentially sensitive to the impact of chronic intermittent ethanol exposure in some, but not all behaviors. Future research is needed to understand the mechanisms of these differential effects. (C) 2018 Elsevier Inc. All rights reserved.
机译：美国和其他国家的人口的平均年龄正在增加。了解老年人口的健康后果至关重要。老年人常常在升高的速度下消耗乙醇，并且在某些情况下在狂欢集中。本研究试图调查与成年雄性和青少年雄性大鼠相比，调查老年雄性大鼠的血液大鼠乙醇暴露是否产生差异健康和行为效应。每隔一天通过腹膜内注射将受试者暴露于1.0g / kg或2.0g / kg乙醇20天，并在各种行为措施和体重上进行测试。诸如诸如乙醇暴露的乙醇暴露对老年和青少年和成年大鼠之间的体重产生差异影响。此外，老年大鼠的抗反射损失明显更长，并在2.0-g / kg暴露后表现出耐受性的趋势。没有明显对焦虑的行为的显着影响，如开放式臂表测量，抑郁症状在强制游泳测试中通过不动的抑郁症状，或通过潜水迷宫中的潜伏和路径长度测量的认知性能。这些结果表明，老年动物对一些慢性间歇性乙醇暴露的影响差异敏感，但不是所有行为。未来的研究是为了了解这些差异效应的机制。 （c）2018年Elsevier Inc.保留所有权利。

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