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The use of chemogenetic approaches in alcohol use disorder research and treatment

机译:在酒精使用障碍研究和治疗中使用化学方法

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Several novel techniques were developed recently to explore neural circuit mechanisms of neuropsychiatric disorders. These techniques include the Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools, which represent valuable platforms for selective and non-invasive control of neural activity with a high degree of spatial resolution. Among all variants, Gq- and Gi-DREADDs are widely used by neuroscientists to dissect out the circuitry and cellular signals. This review is focused on strategies to access a specific neuronal population or circuit using the DREADD technique and summarizes the current knowledge of the DREADDs' application in alcohol use disorder research and therapeutics. (C) 2018 Elsevier Inc. All rights reserved.
机译:最近开发了几种新颖的技术来探索神经精神疾病的神经电路机制。 这些技术包括由设计者药物(Dreadd)的化学工具专门激活的设计者受体,其代表了具有高度空间分辨率的神经活动的选择性和非侵入控制的有价值平台。 在所有变体中,神经电视者广泛使用GQ和GI-Dreadds来解剖电路和蜂窝信号。 本综述专注于使用Dreadd技术进入特定神经元人口或电路的策略,并总结了Dreadds在酒精使用障碍研究和治疗中的Dreadds应用的目前的知识。 (c)2018年Elsevier Inc.保留所有权利。

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