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首页> 外文期刊>Alcohol >Neonatal alcohol exposure augments voluntary ethanol intake in the absence of potentiated anxiety-like behavior induced by chronic intermittent ethanol vapor exposure
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Neonatal alcohol exposure augments voluntary ethanol intake in the absence of potentiated anxiety-like behavior induced by chronic intermittent ethanol vapor exposure

机译：新生酒酒精暴露增加自愿乙醇在没有慢性间歇性乙醇蒸气暴露诱导的诱导有增强的焦虑的行为的情况下摄入

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Individuals fetally exposed to alcohol have a disproportionate risk for developing lifetime alcohol dependence, an association that may be confounded by the presence of comorbid conditions, such as anxiety. Anxiety is also observed following fetal alcohol exposure and is known to exacerbate ethanol consumption, highlighting the utility of animal models to assess this relationship. The present study evaluated the impact of third-trimester equivalent ethanol exposure on ethanol consumption and anxiety-like, marble burying behavior in adult, male C57BL/6 mice following exposure to chronic intermittent ethanol vapor, proposed to model dependence. Neonatal mice (P5-6, 2.5-3.0 g) were administered one injection of saline or ethanol (2.5 g/kg, subcutaneously [s.c.]). Pre-vapor marble burying and limited-access two-bottle choice ethanol intake (15% v/v, 2 h) were comparable in adults (8 weeks of age) across neonatal treatment groups. Five consecutive drinking sessions were repeated 72 h after each weekly ethanol vapor exposure procedure for a total of five vapor/drinking cycles. Consistent with prior research, an increase in voluntary ethanol drinking was observed in vapor-exposed, neonatal saline-treated mice throughout the study starting after the second vapor cycle compared to both air exposed control groups. In neonatal ethanol-treated mice, this increase in ethanol intake and preference following vapor exposure was accelerated, being observed after the first vapor cycle, and observed at an augmented level compared to vapor-exposed, neonatal saline-treated mice and air controls for both neonatal conditions. Conversely, marble burying was enhanced equivalently in vapor-exposed mice from either neonatal treatment group relative to their respective air-exposed controls. These data recapitulate clinical observations of enhanced sensitivity for alcohol dependence following developmental alcohol exposure, which may reflect enhanced motivational drive rather than potentiated negative affect. The present model will facilitate the future exploration of mechanisms that underlie increased risk for alcohol use after early developmental exposure. Published by Elsevier Inc.
机译：令人厌恶的个体暴露于酒精的风险不成比例地发展寿命酒精依赖性，这种关联可能被同种植条件的存在（如焦虑）混淆。胎儿酒精暴露后也观察到焦虑，并且已知加剧乙醇消耗，突出了动物模型的效用来评估这种关系。本研究评估了第三孕孕酮当量乙醇暴露对成人乙醇消费和焦虑，大理石埋葬行为的影响，雄性C57BL / 6小鼠接触后暴露于慢性间歇乙醇蒸气，提出模拟依赖性。施用新生儿小鼠（P5-6，2.5-3.0g）一次注射一次盐水或乙醇（2.5g / kg，皮下注射。蒸汽大理石埋葬和有限公司的双瓶选择乙醇摄入（15％v / v，2 h）在新生儿治疗组中的成人（8周龄）相当。每周乙醇蒸气暴露程序共重复5个连续饮酒会，总共五个蒸气/饮用循环。与现有研究一致，在整个研究中，在第二蒸汽循环与两个空气暴露的对照组相比，在蒸汽暴露的新生儿盐水处理的小鼠中观察到自愿乙醇饮用的增加。在新生儿乙醇处理的小鼠中，在第一蒸汽循环后观察到蒸气暴露后的乙醇摄入和偏好的这种增加，并在增强水平上观察到与蒸气暴露，新生儿处理的小鼠和空气控制相比新生儿条件。相反，在新生儿治疗组相对于各自的空气暴露对照中，在蒸汽暴露的小鼠中等效地增强了大理石埋。这些数据概括了在发育酒精暴露后提高醇依赖性增强敏感性的临床观察，这可能反映增强的动力驱动而不是具有增强的负面影响。本模型将促进未来对早期发育暴露后饮酒风险增加的机制的探讨。 elsevier公司发布

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