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Cross-species molecular dissection across alcohol behavioral domains

机译：酒精行为域的交叉物种分子析分

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摘要

This review summarizes the proceedings of a symposium presented at the “Alcoholism and Stress: A Framework for Future Treatment Strategies” conference held in Volterra, Italy on May 9–12, 2017. Psychiatric diseases, including alcohol-use disorders (AUDs), are influenced through complex interactions of genes, neurobiological pathways, and environmental influences. A better understanding of the common neurobiological mechanisms underlying an AUD necessitates an integrative approach, involving a systematic assessment of diverse species and phenotype measures. As part of the World Congress on Stress and Alcoholism, this symposium provided a detailed account of current strategies to identify mechanisms underlying the development and progression of AUDs. Dr. Sean Farris discussed the integration and organization of transcriptome and postmortem human brain data to identify brain regional- and cell type-specific differences related to excessive alcohol consumption that are conserved across species. Dr. Brien Riley presented the results of a genome-wide association study of DSM-IV alcohol dependence; although replication of genetic associations with alcohol phenotypes in humans remains challenging, model organism studies show thatCOL6A3,KLF12, andRYR3affect behavioral responses to ethanol, and provide substantial evidence for their role in human alcohol-related traits. Dr. Rob Williams expanded upon the systematic characterization of extensive genetic-genomic resources for quantifying and clarifying phenotypes across species that are relevant to precision medicine in human disease. The symposium concluded with Dr. Robert Hitzemann's description of transcriptome studies in a mouse model selectively bred for high alcohol (“binge-like”) consumption and a non-human primate model of long-term alcohol consumption. Together, the different components of this session provided an overview of systems-based approaches that are pioneering the experimental prioritization and validation of novel genes and gene networks linked with a range of behavioral phenotypes associated with stress and AUDs.
机译：本综述总结了在2017年5月9日至12日在意大利举行的“酗酒和压力：未来治疗策略”会议上举行的研讨会的诉讼程序，于2017年5月9日至12日举行。精神疾病，包括酒精使用障碍（AUDS）是通过基因，神经生物学途径和环境影响的复杂相互作用来影响。更好地理解副本的常见神经生物学机制需要一种综合方法，涉及对各种物种和表型测量的系统评估。作为世界压力和酗酒国大会的一部分，该研讨会提供了关于目前策略的详细说明，以确定澳元的发展和进展的基础。 Sean Farris博士讨论了转录组和后期人脑数据的整合和组织，以确定与在物种中保存的过度饮酒相关的脑区域和细胞类型特异性差异。 Brien Riley博士展示了DSM-IV酒精依赖的基因组关联研究结果;虽然具有人类酒精表型的遗传关联的复制仍然有挑战性，但模型生物学研究表明，对乙醇的作用，klf12，klf12，klf12，andryr3，以及对乙醇的作用提供了实质性证据。 Rob Williams博士在系统表征广泛的遗传基因组资源方面，用于量化和澄清与人类疾病精密药物相关的物种的表型。博览会与罗伯特希泽曼博士结束的小鼠模型的描述，选择性地为高级酒精（“狂犬病”）消费和长期醇​​消费的非人类灵长类动物模型进行了结论。本届会议的不同组成部分提供了基于系统的方法概述，这些方法是开创了与与压力和AUDS相关的一系列行为表型相关的新型基因和基因网络的实验优先化和验证。

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