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首页> 外文期刊>Alcohol >Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes
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Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes

机译：压力脆弱性和酒精使用和后果：从人类实验室研究到临床结果

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It is well known that vulnerability to stress is a risk factor for alcohol use disorder (AUD). Chronic alcohol use can result in neuroadaptations in cortico-striatal pathways and hypothalamic pituitary adrenal (HPA) axis function that are manifested in altered behavioral and cognitive control functions contributing to alcohol craving, compulsive motivation, consumption, and consequences. This symposium brings together studies utilizing novel approaches to help improve our understanding of stress – past, acute, and chronic – on alcohol seeking and consumption and related outcomes using a combination of human laboratory models, neuroimaging, and clinical measures. Examining factors that determine vulnerability as well as resilience to stress are of particular interest in the study of AUD because, in addition to increasing our understanding of the risk factors for AUD, such knowledge can be used to develop more effective treatments.Dr. Stangl presented a novel human experimental model that demonstrates, for the first time, stress-induced increases in alcohol self-administration in binge drinkers using a guided imagery paradigm combined with intravenous alcohol self-administration (IV-ASA). Dr. Blaine presented data demonstrating that glucocorticoid response to stress drives compulsive alcohol motivation and intake in binge/heavy drinkers. Dr. Plawecki presented data examining sex differences in the effect of two distinct stress paradigms – mood induction and abstinence – on IV-ASA in moderate drinkers. Dr. Schwandt presented clinical data providing a new perspective on the relationship between childhood trauma and AUD by suggesting possible underlying mechanisms that confer resilience, rather than vulnerability, to severe early life stress exposure.
机译：众所周知，对压力的脆弱性是酒精使用障碍（AUD）的危险因素。慢性醇类可以导致皮质纹脊通途径和下丘脑垂体肾上腺（HPA）轴函数的神经型，这表明在改变的行为和认知控制功能中有助于酒精渴望，强迫动力，消费和后果。该研讨会汇集了利用新方法帮助改善我们对应力，急性和慢性的理解的研究，使用人力实验室模型，神经影像学和临床措施的组合来提高对压力，急性和慢性的理解和相关结果。检查因素确定漏洞以及对应力的抵御能力对澳元的研究特别感兴趣，因为除了增加对澳元的风险因素的理解之外，这些知识也可用于开发更有效的治疗方法.DR。 Stangl介绍了一种新型人类实验模型，首次演示了使用指导图像范式与静脉内酒精自我给药（IV-ASA）相结合的狂暴饮用者中酒精自我管理的饮酒中的饮酒中的增加。 Blaine博士展示了证明对压力的糖皮质激素反应的数据推动了强迫饮酒者的强迫酒精动机和摄入量。 Plawecki博士提出了两种不同的压力范例 - 情绪诱导和禁欲的效果的性差异 - 在适度饮酒者中的IV-ASA。施南特博士展示了临床资料，通过建议可能赋予弹性，而不是脆弱性，而不是脆弱的潜在机制，为童年创伤和澳元之间的关系提供了新的视角。

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