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首页> 外文期刊>Alcohol >Offspring of male rats exposed to binge alcohol exhibit heightened ethanol intake at infancy and alterations in T-maze performance
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Offspring of male rats exposed to binge alcohol exhibit heightened ethanol intake at infancy and alterations in T-maze performance

机译：暴露于泪液醇的雄性大鼠的后代表现出高度的乙醇摄入量，在T-迷宫表现中的改变

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Alcohol use is associated with a variety of negative consequences, including heightened likelihood of cognitive impairment, proclivity to alcohol use disorders (AUD), and alterations in the drinker's offspring. Children and rodents exposed to alcohol during pregnancy, or those whose fathers consumed alcohol prior to mating, often exhibit neurodevelopmental, physiological, and behavioral deficits. The present study assessed cognitive function and alcohol intake in male and female rats that were offspring of alcohol-exposed fathers. Adult male rats were exposed to alcohol or vehicle (0.0 or 2.0 g/kg, respectively; twice daily for 2 days followed by a rest day, for a total of eight alcohol or vehicle exposure days), or were left untreated and then mated with non-manipulated females. The offspring were assessed for alcohol intake, via intraoral infusion, followed by cognitive assessment via an alternating T-maze task. The results indicated that paternal ethanol exposure, prior to breeding, resulted in offspring that consumed significantly more ethanol than vehicle or untreated controls. Furthermore, the offspring of alcohol exposed fathers exhibited a significant failure to initiate and complete the T-maze performance tests. Although, when they did engage in the tests they performed at the level of controls (i.e., 80% correct). The present results add to a growing body of literature suggesting that paternal pre-conception alcohol exposure can have deleterious effects on the offspring. (C) 2018 Elsevier Inc. All rights reserved.
机译：酒精使用与各种负面后果有关，包括认知障碍的可能性加剧，饮酒障碍（AUD）的倾向，以及饮酒者后代的改变。在怀孕期间暴露于酒精的儿童和啮齿动物，或者在交配前父亲消耗酒精的人，通常表现出神经发育，生理和行为赤字。本研究评估了雄性和雌性大鼠的认知功能和酒精摄入量，这些父母大鼠被酗酒的父亲的后代。将成年雄性大鼠暴露于酒精或载体（0.0或2.0g / kg;每天两次2天，然后休息一天，总共八个酒精或载体暴露日），或者没有治疗，然后与之交配非操纵的女性。通过体内输注评估后代的酒精摄入量，然后通过交替的T-MAZE任务进行认知评估。结果表明，在繁殖之前，患者乙醇暴露导致后代，比载体或未治疗的对照产生更高的乙醇。此外，酒精暴露的父亲的后代表现出显着的未能启动和完成T型迷宫性能测试。虽然，当他们从事他们在控制水平上进行的测试时（即80％正确）。目前的结果增加了一种越来越多的文献，表明父亲的预概念酒精暴露可能对后代具有有害影响。 （c）2018年Elsevier Inc.保留所有权利。

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