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首页> 外文期刊>Alcohol >Chronic alcohol consumption from adolescence to adulthood in mice - Hypothalamic gene expression changes in insulin-signaling pathway
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Chronic alcohol consumption from adolescence to adulthood in mice - Hypothalamic gene expression changes in insulin-signaling pathway

机译：从青春期到成年小鼠的慢性醇消耗 - 胰岛素信号通路中的下丘脑基因表达变化

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摘要

Adolescence is a developmental stage vulnerable to alcohol drinking-related problems, and alcohol exposure during adolescence may lead to long-lasting consequences. The hypothalamus is a key brain region for food and water intake regulation as well as weight control, and is one of the alcohol-sensitive brain regions. However, it is not known what the alcohol effect is on the hypothalamus following adolescent alcohol intake, chronically over adolescent development, at moderate levels. We employed a model of chronic moderate alcohol intake from adolescence to adulthood in mice, and analyzed the effect of alcohol on growth and weight gain, as well as hypothalamic gene expression patterns. The results indicated that chronic alcohol consumption during adolescence, even at moderate levels, led to both a reduction in weight gain in mice, and considerable gene expression changes in the hypothalamus. Pathway analysis and real-time PCR identified the type II diabetes mellitus and the insulin-signaling pathways as being the hypothalamic pathways affected by chronic alcohol. Our findings from the mouse alcohol consumption study therefore serve as a potential warning against alcohol consumption during adolescence, such as in teens and college students.
机译：青春期是易受酒精饮用相关问题的发育阶段，青春期期间的酒精暴露可能导致持久的后果。下丘脑是一种用于食物和水摄入调节的关键脑区，以及体重控制，是酒精敏感的脑区之一。然而，它并不知道酒精效应在青少年酒精摄入后的丘脑效果，慢慢性地在中度水平下。我们使用从青春期到成年小鼠的慢性中等酒精摄入量的模型，并分析了酒精对生长和体重增加的影响，以及下丘脑基因表达模式。结果表明青春期期间的慢性醇消耗，即使在中等水平下，也导致小鼠的体重增加减少，下丘脑中的相当大的基因表达变化。途径分析和实时PCR鉴定了II型糖尿病和胰岛素 - 信令途径，作为受慢性醇影响的下丘脑途径。因此，我们的小鼠饮酒研究的发现作为青少年和大学生在青春期和大学生中的酒精消费的潜在警告。

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  • 来源
    《Alcohol》 |2014年第6期|共8页
  • 作者

    WangK.; SongH.; JinM.; XiaoH.; ZhaoG.; ZouH.; YuL.;

  • 作者单位

    Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai China Shanghai;

    Shanghai-MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center;

    Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai China;

    Shanghai-MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center;

    Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai China State Key;

    Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai China State Key;

    Department of Genetics and Center of Alcohol Studies Rutgers University 607 Allison;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 中毒及化学性损害;
  • 关键词

    Adolescence; Chronic alcohol drinking; Gene expression; Hypothalamus; Insulin-signaling pathway; Type II diabetes mellitus;

    机译：青春期;慢性酒精饮用;基因表达;下丘脑;胰岛素 - 信号通路;II型糖尿病;

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