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Emerging roles for ncRNAs in alcohol use disorders

机译:NCRNA在酒精使用障碍中的新兴角色

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Chronic alcohol exposure produces widespread neuroadaptations and alterations in gene expression in human alcoholics and animal models. Technological advances in the past decade have increasingly highlighted the role of non-protein-coding RNAs (ncRNAs) in the regulation of gene expression and function. These recently characterized molecules were discovered to mediate diverse processes in the central nervous system, from normal development and physiology to regulation of disease, including alcoholism and other psychiatric disorders. This review will investigate the recent studies in human alcoholics and rodent models that have profiled different classes of ncRNAs and their dynamic alcohol dependent regulation in brain. (C) 2017 Elsevier Inc. All rights reserved.
机译:慢性酒精曝光产生普遍的神经展开和人类酗酒者和动物模型中基因表达的改变。 过去十年的技术进步越来越多地突出了非蛋白质编码RNA(NCRNA)在基因表达和功能调节中的作用。 这些最近表征的分子被发现在中枢神经系统中介导各种过程,从正常发育和生理学中调节疾病,包括酗酒和其他精神病疾病。 本综述将研究最近在人类酗酒者和啮齿动物模型中的研究,这些模型具有不同类别的NCRNA和其动态酒精依赖调节。 (c)2017年Elsevier Inc.保留所有权利。

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