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Test for association of common variants in GRM7 with alcohol consumption

机译：用酒精消耗测试GRM7中常用变体的关联

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Recent work using a mouse model has identified the glutamate metabotropic receptor 7 (Grm7) gene as a strong candidate gene for alcohol consumption. Although there has been some work examining the effect of human glutamate metabotropic receptor 7 (GRM7) polymorphisms on human substance use disorders, the majority of the work has focused on other psychiatric disorders such as ADHD, major depressive disorder, schizophrenia, bipolar disorder, panic disorder, and autism spectrum disorders. The current study aimed to evaluate evidence for association between GRM7 and alcohol behaviors in humans using a single nucleotide polymorphism (SNP) approach, as well as a gene-based approach. Using 1803 non-Hispanic European Americans (EAs) (source: the Colorado Center on Antisocial Drug Dependence [CADD)) and 1049 EA subjects from an independent replication sample (source: the Genetics of Antisocial Drug Dependence [GADD)), two SNPs in GRM7 were examined for possible association with alcohol consumption using two family-based association tests implemented in FBAT and QTDT. Rs3749380 was suggestively associated with alcohol consumption in the CADD sample (p = 0.010) with the minor T allele conferring risk. There was no evidence for association in the GADD sample. A gene-based test using four Genome-Wide Association Studies (GWAS) revealed no association between variation in GRM7 and alcohol consumption. This study had several limitations: the SNPs chosen likely do not tag expression quantitative trait loci; a human alcohol consumption phenotype was used, complicating the interpretation with respect to rodent studies that found evidence for a cis-regulatory link between alcohol preference and Grm7; and only common SNPs imputed in all four datasets were included in the gene-based test. These limitations highlight the fact that rare variants, some potentially important common signals in the gene, and regions farther upstream were not examined. (C) 2016 Elsevier Inc. All rights reserved.
机译：使用小鼠模型的最近的作品已经将谷氨酸代谢受体7（GRM7）基因鉴定为醇消耗的强烈候选基因。虽然有一些作品检查人类谷氨酸代谢受体7（GRM7）多态性对人体物质使用障碍的影响，但大多数工作都集中在其他精神疾病，如ADHD，重大抑郁症，精神分裂症，双相情感障碍，恐慌紊乱和自闭症谱系障碍。目前的研究旨在使用单一核苷酸多态性（SNP）方法以及基于基于基于基因的方法来评估人类GRM7和酒精行为之间的关联的证据。使用1803个非西班牙裔美国人（EAS）（资料来源：对抗视野依赖性的Colorado中心[CADD））和1049个EA受试者来自独立复制样品（来源：反社会药物依赖的遗传学[GADD），两个SNP通过在FBAT和QTDT中实施的两个基于基于家庭的协会测试来检查GRM7是否可能与酒精消费相关联。 RS3749380暗示与CADD样品中的酒精消耗有关（P = 0.010），具有次要的核心危险的危险。 Gadd样本中没有证据表明。使用四种基因组关联研究（GWAS）的基因基因试验显示GRM7和醇消耗的变异之间没有关联。本研究有几个限制：所选的SNP可能不会标记表示数量特质基因座;使用人醇消耗表型，使对啮齿动物研究的解释复杂化，发现醇偏好与GRM7之间的顺式调节联系的证据;只有在基于基因的测试中包含在所有四个数据集中累积的常见SNP。这些限制突出了稀有变体，基因中一些潜在重要的常见信号的事实，并且没有检查上游更远的地区。 （c）2016年Elsevier Inc.保留所有权利。

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