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首页> 外文期刊>Alcohol >Difference in sensitivities of blood HDL cholesterol and LDL cholesterol levels to alcohol in middle-aged Japanese men
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Difference in sensitivities of blood HDL cholesterol and LDL cholesterol levels to alcohol in middle-aged Japanese men

机译：中年日男性血液HDL胆固醇和LDL胆固醇水平对酒精的敏感性差异

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Blood HDL cholesterol and LDL cholesterol levels are known to be higher and lower, respectively, in drinkers than in nondrinkers, and the beneficial effects of alcohol on cholesterol metabolism are thought to mainly explain the lower risk for ischemic heart disease in light-to-moderate drinkers than in nondrinkers. However, it remains unknown whether sensitivities of HDL and LDL cholesterol levels to alcohol are different or not. The subjects of this study were 21,572 middle-aged Japanese men, and they were divided into three tertile groups for blood HDL cholesterol levels. The relationships between habitual alcohol intake and LDL cholesterol levels were investigated in each tertile for HDL cholesterol. In all of the tertile groups for HDL cholesterol, mean LDL cholesterol levels were significantly lower in the drinking subgroups than in the nondrinking subgroup and tended to be lower with an increase of alcohol intake. In all of the tertile groups for HDL cholesterol, odds ratios for high LDL cholesterol of each drinking subgroup vs. the nondrinking subgroup were significantly lower than the reference level of 1.00, and also tended to be lower with an increase of alcohol intake. The odds ratios of each drinking subgroup tended to be lower in the 1st tertile group for HDL cholesterol than in the 3rd tertile group. Drinkers in the 1st tertile for HDL cholesterol are thought to have relatively low sensitivity of HDL cholesterol to alcohol, but clearly showed lower LDL cholesterol levels than those found in nondrinkers. Therefore, the sensitivity of LDL cholesterol level to alcohol is different from the sensitivity of HDL cholesterol level to alcohol.
机译：已知血液HDL胆固醇和LDL胆固醇水平分别较高，饮用者较低，而不是在非数字剂中，并且醇对胆固醇代谢的有益作用主要被认为是在光到中等的缺血性心脏病的风险较低饮酒者比在非数字运动员身上。然而，它仍然未知是否对醇的HDL和LDL胆固醇水平的敏感性不同或不不同。本研究的主题是21,572个中年日男性，它们分为三个血液HDL胆固醇水平的三分之一。在每条氮素中研究了习惯性醇摄入量和LDL胆固醇水平的关系，用于HDL胆固醇。在HDL胆固醇的所有三分之一的三组中，在饮用亚组中的平均值LDL胆固醇水平明显低于非重定亚组，并且随着酒精摄入量的增加而趋于较低。在HDL胆固醇的所有三组织中的所有三分之一的液体中，每个饮用亚组的高等LDL胆固醇的差比对于1.00的参考水平显着低于1.00，并且随着酒精摄入量的增加也趋于降低。每种饮用亚组的差距趋于低于第1型胆固醇的第1型胆固醇的差异比在第3条核苷酸基团中较低。对于HDL胆固醇的第1型Tertile的饮酒者被认为具有对酒精的HDL胆固醇的敏感性相对较低，但清楚地显示出低于非洲产品中的LDL胆固醇水平。因此，LDL胆固醇水平与醇的敏感性不同于HDL胆固醇水平对醇的敏感性。

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