...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alcohol >An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice
【24h】

An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice

机译：酒精戒断测试电池测量小鼠中的多种行为症状

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Despite acceptance that risk for alcohol-use disorder (AUD) has a large genetic component, the identification of genes underlying various components of risk for AUD has been hampered in humans, in part by the heterogeneity of expression of the phenotype. One aspect of AUD is physical dependence. Alcohol withdrawal is a serious consequence of alcohol dependence with multiple symptoms, many of which are seen in multiple species, and can be experienced over a wide-ranging time course.In the present three studies, we developed a battery of withdrawal tests in mice, examining behavioral symptoms from multiple domains that could be measured over time. To permit eventual use of the battery in different strains of mice, we used male and female mice of a genetically heterogeneous stock developed from intercrossing eight inbred strains.Withdrawal symptoms were assessed using commonly used tests after administration of ethanol in vapor for 72 continuous hours. We found significant effects of ethanol withdrawal versus air-breathing controls on nearly all symptoms, spanning 4 days following ethanol vapor inhalation. Withdrawal produced hypothermia, greater neurohyperexcitability (seizures and tremor), anxiety-like behaviors using an apparatus (such as reduced transitions between light and dark compartments), anhedonia (reduced sucrose preference), Straub tail, backward walking, and reductions in activity; however, there were no changes in thermal pain sensitivity, hyper-reactivity to handling, or anxiety-like emergence behaviors in other apparatus. Using these data, we constructed a refined battery of withdrawal tests. Individual differences in severity of withdrawal among different tests were weakly correlated at best. This battery should be useful for identifying genetic influences on particular withdrawal behaviors, which should reflect the influences of different constellations of genes.
机译：尽管验收了饮酒障碍（AUD）的风险具有大型遗传成分，但鉴定患病风险风险的各种组成部分的基因已经阻碍了人类，部分是表型表达的异质性。澳元的一个方面是物理依赖。酒精戒断是酒精依赖性与多种症状的严重后果，其中许多在多种物种中看到，并且可以在广泛的时间课程中经历。在本发明的三项研究中，我们在小鼠中开发了电池的戒断试验，检查可以随时间测量的多个域的行为症状。为了允许最终使用不同菌株的小鼠的电池，我们使用从间歇八种血液中产生的遗传异质股票的雄性和女性小鼠。在蒸汽中乙醇施用乙醇72的常用测试中，评估了常用的测试。我们发现乙醇戒断与空气呼吸控制几乎所有症状的显着效果，在乙醇蒸气吸入后4天跨越4天。戒断产生的体温过低，更大的神经痛可征收性（癫痫发作和震颤），使用一种装置（如光和黑暗隔室之间的过渡），蒽胺（减少蔗糖偏好），横向尾，向后行走和减少活性;然而，热疼痛敏感性，对其他装置中的焦虑良好行为的热疼痛敏感性，超反应性的变化。使用这些数据，我们构建了一种提取测试的精制电池。不同测试中的戒断严重程度的个体差异是弱效应。这种电池应该有助于识别特定的戒断行为的遗传影响，这应该反映不同星座的基因的影响。

著录项

  • 来源
    《Alcohol》 |2018年第2018期|共17页
  • 作者

    Pamela Metten; Jason P. Schlumbohm; Lawrence C. Huang; Gian D. Greenberg; Wyatt R. Hack; Stephanie E. Spence; John C. Crabbe;

  • 作者单位

    VA Portland Health Care System and Department of Behavioral Neuroscience Oregon Health &

    Science;

    VA Portland Health Care System and Department of Behavioral Neuroscience Oregon Health &

    Science;

    VA Portland Health Care System and Department of Behavioral Neuroscience Oregon Health &

    Science;

    VA Portland Health Care System and Department of Behavioral Neuroscience Oregon Health &

    Science;

    VA Portland Health Care System and Department of Behavioral Neuroscience Oregon Health &

    Science;

    VA Portland Health Care System and Department of Behavioral Neuroscience Oregon Health &

    Science;

    VA Portland Health Care System and Department of Behavioral Neuroscience Oregon Health &

    Science;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 中毒及化学性损害;
  • 关键词

    Alcohol withdrawal syndrome; Behavioral domains; Mouse; Test battery;

    机译：酒精戒断综合征;行为域;鼠标;测试电池;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号