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首页> 外文期刊>Alcohol >Ethanol intake inhibits growth of the epithelium in the intestine of pregnant rats.
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Ethanol intake inhibits growth of the epithelium in the intestine of pregnant rats.

机译：乙醇摄入量抑制孕鼠肠道上皮的生长。

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摘要

The effects of ethanol ingestion on jejunal and ileal epithelial cells were studied in pregnant rats by measuring crypt and villus cell population, crypt cell proliferation, and crypt cell cycle time as parameters. Timed-pregnancy female rats were fed a liquid diet containing either ethanol [designated as ethanol-fed group (EFG)] or an isocaloric amount of carbohydrate [designated as pair-fed group (PFG)] from gestational day 2 up to delivery. Daily diet ingestion, body weight, nitrogen balance, and nitrogen digestibility were assessed during the gestational period. Crypt and villus cell population, crypt cell proliferation, and crypt cell cycle time were measured in the maternal small intestine at the time animals were killed, just after delivery. Ethanol consumption resulted in ileal hypoplasia of the crypt and villus, but only the villus showed hypoplasia in the jejunum. In addition, crypt cell proliferation was markedly decreased, whereas crypt cell cycle time was longer, both in the jejunum and ileum of the EFG. Ethanol ingestion had no significant effect on body weight gain, nitrogen balance, and nitrogen digestibility. According to our expectations, the offspring from the EFG had significantly lower body weight. In conclusion, chronic ethanol ingestion during pregnancy inhibited the maternal intestinal epithelium growth, more extensively in the ileum.
机译：通过测量Crypt和绒毛细胞群，隐窝细胞增殖和Crypt细胞循环时间，在孕大鼠中研究了乙醇对血管和肠上皮细胞对JEUNAL和ILEAL上皮细胞的影响。将妊娠雌性大鼠喂养含有乙醇的液体饮食[指定为乙醇 - 喂养基团（EFG）]或碳水化合物的异马尔数量[指定为对喂养基团（PFG）]，从妊娠期2天递送到递送。在妊娠期期间评估每日饮食摄入，体重，氮气平衡和氮气消化率。隐藏和绒毛群体，隐窝细胞增殖和隐窝细胞周期时间在动物杀死的母体小肠中测量，递送后。乙醇消费导致隐窝和绒毛的肠道骨膜发育不全，但只有绒毛在Jejunum展示过次痛苦。此外，隐窝细胞增殖显着降低，而Crypt细胞周期时间较长，两者在Jejunum和EFG的回肠内。乙醇摄入对体重增加，氮气平衡和氮气消化率没有显着影响。根据我们的期望，EFG的后代显着降低了体重。总之，妊娠期间的慢性乙醇摄入抑制了母体肠上皮生长，更广泛地在回肠中。

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