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Asialo-transferrin: Biochemical aspects and association with alcohol abuse investigation

机译：asialo-transferrin：生化方面和与酒精滥用调查的关联

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Asialo-human transferrin (asialo-hTf) is a glycoform of the human serum protein transferrin characterized by the lack of the sialic acid (SA) terminal unit. It is known that glycosylation micro-heterogeneity and the presence of SA are strongly involved in protein functioning and pathophysiological activities. Some hTf glycoforms are valuable biomarkers for the detection of both genetic defects of glycosylation and/or sialoform distribution changes. The detection of the carbohydrate deficient transferrin (CDT) glycoforms is currently a widely employed method for the diagnosis of chronic alcohol abuse. The physiological significance of asialo-hTf is still unclear, despite its important biological implications. The current knowledge suggests that asialo-hTf may be involved in regulation of iron transport and release at the hepatic level, which, consequently, could strongly be affected by alcohol consumption. For these reasons, a deeper understanding of asialo-hTf structure and its physiological role is required, and an improved method of its analysis would favor the detection of both chronic abuse and other habits of alcohol intake and/or misuse. Thus, suitable analytical methods possessing higher sensitivity and specificity in comparison with the currently available techniques are certainly recommended. The present review summarizes the studies on asialo-hTf structure, roles, and detection techniques mainly in relation to its possible use as a potentially additional useful biomarker of alcohol abuse, and underlines its prospective value as a forensic and diagnostic tool. (C) 2019 Elsevier Inc. All rights reserved.
机译：Asialo-人转移素（Asialo-HTF）是人血清蛋白转移素的糖型，其特征在于缺乏唾液酸（SA）终端单元。众所周知，糖基化微异均性和SA的存在强烈地参与蛋白质功能和病理生理学活动。一些HTF糖型是有价值的生物标志物，用于检测糖基化和/或唾液管分布变化的遗传缺陷。检测碳水化合物缺陷型转移素（CDT）甘油膜目前是诊断慢性酒精滥用的广泛采用的方法。尽管其重要的生物学意义，Asialo-HTF的生理意义尚不清楚。目前的知识表明，ASialo-HTF可能参与铁运输的调节，并在肝水平下释放，从而强烈影响酒精消耗。由于这些原因，需要更深入地了解ASIalo-HTF结构及其生理作用，并且其分析的改进方法将有利于检测慢性滥用和其他酒精摄入习惯和/或滥用。因此，肯定建议使用具有更高灵敏度和特异性的合适的分析方法。本综述总结了对ASIALO-HTF结构，角色和检测技术的研究主要是与其可能的用途作为饮酒滥用的可能额外的有用生物标志物，并将其潜在价值提高为法医和诊断工具。 （c）2019 Elsevier Inc.保留所有权利。

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