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首页> 外文期刊>Alcohol >The alpha 3 beta 4 nicotinic acetylcholine receptor antagonist 18-Methoxycoronaridine decreases binge-like ethanol consumption in adult C57BL/6J mice
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The alpha 3 beta 4 nicotinic acetylcholine receptor antagonist 18-Methoxycoronaridine decreases binge-like ethanol consumption in adult C57BL/6J mice

机译：α3β4烟碱乙酰胆碱受体拮抗剂18-甲氧基丙酮降低成人C57BL / 6J小鼠的静脉样乙醇消耗

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Binge alcohol drinking is a health burden in the United States, which has an alarming economic impact. Unfortunately, medications available for alcohol abuse have low efficacy or adverse side effects, creating a need to evaluate novel therapies. Growing research suggests that 18-Methoxycoronaridine (18-MC), an alpha 3 beta 4 nicotinic acetylcholine receptor (nAChR) antagonist, may be effective at reducing ethanol consumption. However, its effects on binge-like ethanol consumption and other ethanol behaviors have not been examined. The present study examined the effect of alpha 3 beta 4 nAChRs antagonism on basal locomotor activity in male and female C57BL/6J mice. Next we tested the effect of 18-MC on binge-like ethanol consumption, ethanol-induced sedation, and ethanol metabolism. Finally, we tested the effect of alpha 3 beta 4 nAChRs on saccharin consumption to ensure effects were specific for ethanol. We observed that 18-MC decreased binge-like ethanol consumption without altering saccharin consumption, the sedative effects of ethanol, or ethanol metabolism. High doses of 18-MC caused locomotor sedation in C57BL/6J mice, but the effects were brief and likely did not contribute to differences in ethanol consumption. Our results support the involvement of the alpha 3 beta 4 nAChRs in binge-like ethanol intake, and further work should explore the use of 18-MC for treatment of alcohol use disorders. (C) 2018 Elsevier Inc. All rights reserved.
机译：狂欢酒精饮酒是美国的健康负担，具有令人震惊的经济影响。遗憾的是，可用于酒精滥用的药物具有低疗效或不良副作用，创造需要评估新疗法。越来越多的研究表明，18-甲氧基丙氨酸（18-MC），α3β4烟碱乙酰胆碱受体（NACHR）拮抗剂可有效降低乙醇消耗。然而，尚未检查其对诸如紫红素的乙醇消费和其他乙醇行为的影响。本研究检测了α3β4NACHRS对雄性和雌性C57BL / 6J小鼠基底运动活性的影响。接下来，我们测试了18-MC对静乙醇消耗，乙醇诱导的镇静和乙醇代谢的影响。最后，我们测试了α3β4NACHRS对糖精消耗的影响，以确保效果特异于乙醇。我们观察到18-mc降低静脉乙醇消耗，而不改变糖精消耗，乙醇的镇静作用，或乙醇代谢。高剂量的18-MC导致C57BL / 6J小鼠的运动镇静，但效果简短，可能对乙醇消费没有贡献。我们的结果支持α3β4NACHRS在诸如麦芽样乙醇摄入中的参与，进一步的工作应探讨18-MC治疗酒精使用障碍的使用。 （c）2018年Elsevier Inc.保留所有权利。

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