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Molecular tools to elucidate factors regulating alcohol use

机译:用于阐明调节酒精使用的因素的分子工具

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摘要

Alcohol use disorder (AUD) is a pervasive societal problem, marked by high levels of alcohol intake and recidivism. Despite these common disease traits, individuals diagnosed with AUD display a range of disordered drinking and alcohol-related behaviors. The diversity in disease presentation, as well as the established polygenic nature of the disorder and complex neurocircuitry, speaks to the variety of neurochemical changes resulting from alcohol intake that may differentially regulate alcohol-related behaviors. Investigations into the molecular adaptations responsible for maladaptive alcohol-related behavioral outcomes require an ever-evolving set of molecular tools to elucidate with increasing precision how alcohol alters behavior through neurochemical changes. This review highlights recent advances in molecular methodology, addressing how incorporation of these cutting-edge techniques not only may enhance current knowledge of the molecular bases of AUD, but also may facilitate identification of improved treatment targets that may be therapeutic in specific subpopulations of AUD individuals. (C) 2018 Elsevier Inc. All rights reserved.
机译:酒精使用障碍(AUD)是一种普遍的社会问题,标志着高水平的酒精摄入和累犯。尽管有这些常见的疾病性状,但诊断患有AUD的个体显示一系列无序的饮酒和与酒精相关的行为。疾病介绍的多样性,以及疾病和复杂神经障碍的既定的多种​​子态性质,与醇摄入量导致的各种神经化学变化谈论,这可能会差异调节与酗酒相关的行为。调查负责适用于不适的饮酒相关的行为结果的分子适应需要一组不断发展的分子工具,以促进较高的精确度通过神经化学变化改变行为。该综述突出了分子方法论的最新进展,解决这些前沿技术的融合不仅可以增强目前对澳元的分子基础的知识,而且还可以促进鉴定可能是治疗的改进的治疗目标,这些目标可能是治疗的AUD个人的特定群体。 (c)2018年Elsevier Inc.保留所有权利。

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