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首页> 外文期刊>Alcohol >Prenatal ethanol exposure potentiates isolation-induced ethanol consumption in young adult rats
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Prenatal ethanol exposure potentiates isolation-induced ethanol consumption in young adult rats

机译：产前乙醇曝光增强了幼年大鼠中的分离诱导的乙醇消费

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Prenatal and/or early postnatal ethanol exposure (PEE) is associated with significant behavioral and physiological deficits in offspring, including alterations in stress response systems and a greater likelihood of alcohol use disorders. Stress-induced ethanol drinking after PEE, however, has been largely unexplored. The present study analyzed ethanol intake in male Sprague-Dawley rats after protracted prenatal and early postnatal ethanol exposure and tested whether social isolation during the sensitive period of adolescence modulates the effects of PEE on ethanol drinking. The dams were given 10% ethanol (or its vehicle) as the sole drinking fluid from gestational day 0 (GDO) to postnatal day 7 (PD7). On PD21, male offspring were housed individually (isolated housing group) or in pairs in standard cages (standard housing group). From PD56 to PD84, these male rats were tested for ethanol intake in 24-h, intermittent two-bottle choice sessions that were conducted across 4 weeks. Maternal ethanol consumption during gestation and during the first week of life of the offspring averaged 6.10-8.20 g/kg/22 h. Isolation housing during adolescence increased free-choice ethanol drinking in young adulthood. The main novel finding was that this facilitative effect of isolation on absolute and percent ethanol intake was significantly greater in PEE rats than in control counterparts not exposed to the prenatal and early postnatal ethanol exposure (effect sizes [eta(2)p]: 0.24-0.32). The present results suggest that PEE renders the individual sensitive to the facilitative effect of stress exposure on ethanol intake. (C) 2018 Elsevier Inc. All rights reserved.
机译：产前和/或早期的后乙醇暴露（小便）与后代的显着行为和生理缺陷有关，包括压力反应系统的改变以及醇类使用障碍的更大可能性。然而，撒尿后的应激诱导的乙醇饮酒在很大程度上是未开发的。本研究分析了在持续的产前和早期产前乙醇暴露后的雄性Sprague-Dawley大鼠中的乙醇摄入并测试了在青春期敏感期间的社会分离调节对乙醇饮用的影响。将坝10％乙醇（或其车辆）作为来自妊娠期0（GDO）至产前期7（PD7）的唯一饮用液。在PD21上，雄性后代被单独地（隔离住房组）或成对的标准笼（标准外壳组）。从PD56到PD84，测试这些雄性大鼠在24小时内进行乙醇摄入，间歇性的两瓶选择会话，这些次在4周内进行。孕产妇乙醇消耗在妊娠期间和在后代的第一周期间的后期平均为6.10-8.20克/千克/ 22小时。青春期期间的隔离壳体增加了年轻成年期饮用的自由选择乙醇。主要的新发现是，小便大鼠的促进对绝对和乙醇摄入量的这种促进效果显着大于未暴露于产前和早期产前乙醇暴露的对应物（效果大小[ETA（2）P]：0.24- 0.32）。本结果表明，小便使个人对压力暴露对乙醇摄入量的促进作用的敏感性。 （c）2018年Elsevier Inc.保留所有权利。

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