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首页> 外文期刊>AJRI: American Journal of Reproductive Immunology >Predictive value of thromboelastography parameters combined with antithrombin III and D‐Dimer in patients with recurrent spontaneous abortion
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Predictive value of thromboelastography parameters combined with antithrombin III and D‐Dimer in patients with recurrent spontaneous abortion

机译：血栓球摄影参数与抗血栓III和D-二聚体在复发性自发性流产患者中的预测值

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摘要

Problem To investigate the value of thromboelastography (TEG) combined with antithrombin III (AT‐III) and D‐Dimer in predicting the occurrence of recurrent spontaneous abortion (RSA). Method of study One hundred and five RSA patients and 40 fertile women were enrolled. The subjects were subjected into four groups: group 1 (40 fertile women), group 2 (58 women with 2 abortions), group 3 (30 women with 3 abortions), and group 4 (17 women with four abortions). TEG was conducted on all subjects. Clotting time, reaction time, angle degree, coagulation index, and maximum amplitude were measured. The levels AT‐III, D‐Dimer, platelet counts, and fibrinogen concentration were determined. The ROC curve analysis was done using MedCalc software to analyse the diagnosis accuracy of the parameters of interest and the combined approach. Results The AT‐III level in all group 4 was significantly lower than in fertile women. The D‐Dimer concentration, platelet count, and MA in patients with four prior abortions were significantly higher than the other three groups. CI and fibrinogen concentration in patients with four prior pregnancy losses were significantly higher than group 1. The ROC curves suggested that combined use of CI, MA, AT‐III, and D‐Dimer was with the highest accuracy 92.8%, thus predicting the most accurate diagnosis for RSA. Conclusion Recurrent spontaneous abortion is associated with abnormal coagulation and anticoagulation. TEG combined with detection of AT‐III and D‐Dimer levels can distinguish patient with RSA from those with normal fertility and highly possibly predict the occurrence of RSA.
机译：研究促进血栓间隙（TEG）的值与抗凝血酶III（AT-III）和D-二聚体相结合预测复发性自发性流动（RSA）的发生。学习方法一百五名RSA患者和40名肥沃妇女。将受试者进行四组：第1组（40名肥沃妇女），第2组（58名患有2名堕胎的妇女），第3组（30名妇女3名堕胎）和第4组（17名堕胎的妇女）。 TEG在所有受试者上进行。测量凝血时间，反应时间，角度，凝固指数和最大振幅。测定-III，D-二聚体，血小板计数和纤维蛋白原浓度的水平。使用MEDCALC软件进行ROC曲线分析，分析兴趣参数和组合方法的诊断准确性。结果所有组4中的III水平明显低于肥沃妇女。四个先前牵种患者的D-二聚体浓度，血小板计数和MA显着高于其他三组。患有四个先前妊娠损失的患者的CI和纤维蛋白原浓度明显高于1。ROC曲线表明CI，MA，III和D-二聚体的结合使用的最高精度为92.8％，从而预测最多准确诊断RSA。结论复发性自发流产与异常凝血和抗凝有关。 TEG联合检测AT-III和D-二聚体水平可以将患者与具有正常生育能力的RSA区分，并且可以高可能预测RSA的发生。

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