Direct design of pharmaceutical antisolvent crystallization through concentration control

Zhou GX; Fujiwara M; Woo XY; Rusli E; Tung HH; Starbuck C; Davidson O; Ge ZH; Braatz RD

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Direct design of pharmaceutical antisolvent crystallization through concentration control

机译：通过浓度控制直接设计药物抗溶剂结晶

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Recent advances in in situ measurement technology and automation of batch crystallizers have enabled the development of batch crystallization recipes in which the desired supersaturation profile is followed by feedback control. This paper describes a new approach for following supersaturation setpoints for antisolvent crystallizations that is easy to implement for the tried crystallization. Simulations and application to a proprietary drug compound demonstrate how this combination of automation and in process measurements enables the rapid development of batch crystallization processes in the pharmaceutical industry.

机译：现场测量技术和间歇结晶器自动化的最新进展使得间歇结晶配方的开发成为可能，其中所需的过饱和度曲线随后是反馈控制。本文介绍了一种新的方法，用于遵循反溶剂结晶的过饱和设定点，对于尝试的结晶很容易实现。对专有药物化合物的仿真和应用表明，自动化和过程测量的这种结合如何使制药行业中的批量结晶过程快速发展。

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来源
《Crystal growth & design》 |2006年第4期|共7页
作者
Zhou GX; Fujiwara M; Woo XY; Rusli E; Tung HH; Starbuck C; Davidson O; Ge ZH; Braatz RD;
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原文格式 PDF
正文语种 eng
中图分类晶体学;
关键词
ATR-FTIR SPECTROSCOPY; ACETONE-WATER MIXTURES; CONCENTRATION PREDICTION; COOLING CRYSTALLIZATION; BATCH CRYSTALLIZATION; LASER BACKSCATTERING; PARACETAMOL; SIZE; OPTIMIZATION; CHEMOMETRICS;

机译：ATR-FTIR光谱;乙炔水混合物;浓度预测;冷却结晶;分批结晶;激光背散射;对羟基苯酚;尺寸;优化;化学计量学;

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专利

1. Direct design of pharmaceutical antisolvent crystallization through concentration control [J] . Zhou GX, Fujiwara M, Woo XY, Crystal growth & design . 2006,第4期

机译：通过浓度控制直接设计药物抗溶剂结晶
2. Polymorphic Control and Scale-Up Strategy for Antisolvent Crystallization Using a Sequential Supersaturation and Direct Nucleation Control Approach [J] . Ostergaard Iben, Szilagyi Botond, de Diego Heidi Lopez, Crystal growth & design . 2020,第8期

机译：使用顺序过饱和和直接成核控制方法进行多态性控制和抗溶剂结晶的扩大策略
3. Polymorphic Control and Scale-Up Strategy for Antisolvent Crystallization Using Direct Nucleation Control [J] . Ostergaard Iben, Szilagyi Botond, de Diego Heidi Lopez, Crystal growth & design . 2020,第4期

机译：用直接成核控制进行抗溶剂结晶多态性控制和扩大策略
4. Supersaturation Control Based Direct Design of Pharmaceutical Crystallization using ATR UV/Vis and FBRM [C] . A Saleemi, ZK Nagy, C Rielly International Workshop on Industrial Crystallization . 2008

机译：基于体验控制使用ATR UV / Vis和FBRM的药物结晶直接设计
5. Supercritical crystallization of pharmaceuticals: The gas antisolvent process. [D] . Bakhbakhi, Yousef. 2005

机译：药物的超临界结晶：气体反溶剂工艺。
6. Controlled Size Growth of Thermally Stable OrganometallicHalide Perovskite Microrods: Synergistic Effect of Dual-Doping LatticeStrain Engineering Antisolvent Crystallization and Band Gap TuningProperties [O] . Mohammed Nazim, Jae Hyun Kim 2020

机译：热稳定的有机金属的受控尺寸增长卤化物钙钛矿微棒：双重掺杂晶格的协同效应应变工程抗溶剂结晶和带隙调整物产
7. ADVANCED CONTROL STRATEGIES FOR PHARMACEUTICAL ANTISOLVENT CRYSTALLIZATION PROCESSES [O] . VAMSI KRISHNA KAMARAJU 2014

机译：药物抗溶剂结晶过程的高级控制策略

Direct design of pharmaceutical antisolvent crystallization through concentration control

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