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The Unmysterious Roles of HSP90: Ovarian Pathology and Autoantibodies

机译:HSP90的甲虫作用:卵巢病理和自身抗体

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摘要

The heat shock proteins (HSPs) are a group of evolutionarily conserved proteins with important physiological functions, whose synthesis is enhanced by elevated temperature or other stresses. HSPs show high sequence homology between different species, from bacteria to humans. Despite the significant degree of evolutionary conservation, HSPs are highly immunogenic. Of the several HSPs, HSP90 is an abundant, constitutively expressed chaperone constituting around 1-2% of total cellular protein under non-stress conditions. This protein from even the most distantly related eukaryotes has 50% amino acid identity, and all have more than 40% identity with the Escherichia coli protein.
机译:热休克蛋白(HSP)是一组具有重要生理功能的进化保守蛋白质,其合成通过升高的温度或其他应力增强。 HSP在不同物种之间显示出高序列同源性,从细菌到人类。 尽管存在显着的进化守恒程度,但HSP是高度免疫原性的。 在几种HSP的中,HSP90是一种丰富,组成的伴随在非应激条件下约1-2%的总细胞蛋白质的组成伴随的伴侣。 这种蛋白质来自甚至最恒定的相关真核生物具有50%的氨基酸同一性,并且所有具有超过40%的同一性与大肠杆菌蛋白质。

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