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Chapter 6 Herpesvirus Capsid Assembly and DNA Packaging

机译:第6章Herpesvirus Capsid组装和DNA包装

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6.1 The Herpesvirus Virion The mature HSV-1 virion is pleomorphic but largely spherical, with an average diameter of 186 nm at the base of the envelope that extends to approximately 225 nm when the glycoprotein spikes are included (Grunewald et al. 2003) (Fig. 6.1). Like all members of Herpesviridae, the HSV-1 virion is composed of four main architectural features: envelope, tegument, capsid, and the viral genome (Pellet and Roizman 2007). The outer envelope is arranged as a lipid bilayer containing multiple copies of approximately 11 viral glycoproteins that protrude externally and a small number of intrinsic membrane proteins (Eisenberg et al. 2011). The envelope is obtained from the host cell and possesses lipid content similar to that found in the cellular cytoplasmic membrane (Spear and Roizman 1967; van Genderen et al. 1994).
机译:6.1 Herpesvirus病毒群岛成熟的HSV-1病毒粒子是填充但很大程度的球形,平均直径为186nm,在包括糖蛋白尖峰时延伸至约225nm(Grunewald等,2003)(图 。6.1)。 与Herpesviridae的所有成员一样,HSV-1病毒群岛由四个主要的建筑特征组成:信封,Tegument,Capsid和病毒基因组(颗粒和Roizman 2007)。 外壳布置为含有大约11个病毒糖蛋白的多个拷贝的脂质双层,其突出外部和少量的内在膜蛋白(Eisenberg等,2011)。 封套是从宿主细胞获得的,并且具有与细胞细胞质膜(Spear和Roizman 1967; Van Genderen等人1994)中发现的脂质含量。

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