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首页> 外文期刊>Advances in anatomy embryology and cell biology. >Chromatin Remodelling Proteins and Cell Fate Decisions in Mammalian Preimplantation Development
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Chromatin Remodelling Proteins and Cell Fate Decisions in Mammalian Preimplantation Development

机译：染色质改造蛋白质和细胞命运在哺乳动物的预催化发育中的决定

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摘要

The very first cell divisions in mammalian embryogenesis produce a ball of cells, each with the potential to form any cell in the developing embryo or placenta. At some point, the embryo produces enough cells that some are located on the outside of the embryo, while others are completely surrounded by other cells. It is at this point that cells undergo the very first lineage commitment event: outer cells form the trophectoderm and lose the potential to form embryonic lineages, while inner cells form the Inner Cell Mass, which retain embryonic potential. Cell identity is defined by gene expression patterns, and gene expression is largely controlled by how the DNA is packaged into chromatin. A number of protein complexes exist which are able to use the energy of ATP to remodel chromatin: that is, to alter the nucleosome topology of chromatin. Here, we summarise the evidence that chromatin remodellers play essential roles in the successful completion of preimplantation development in mammals and describe recent efforts to understand the molecular mechanisms through which chromatin remodellers facilitate the successful completion of the first cell fate decisions in mammalian embryogenesis.
机译：哺乳动物胚胎发生中的第一细胞分裂产生细胞球，各自具有在发育胚胎或胎盘中形成任何细胞的潜力。在某些时候，胚胎产生足够的细胞，其中一些细胞位于胚胎的外侧，而其他细胞完全被其他细胞包围。在此目前，细胞经历第一谱系承诺事件：外细胞形成肾小管胚胎，并且失去形成胚胎谱系的潜力，而内细胞形成内部电池质量，其保持胚胎潜力。细胞同一性由基因表达模式定义，并且基因表达大大控制了DNA将DNA包装成染色质。存在许多能够利用ATP的能量来改造染色质的蛋白质复合物：即，改变染色质的核心拓扑。在这里，我们总结了染色质雷阵列在成功完成哺乳动物的预催化发育中发挥基本作用的证据，并描述了迄今为止染色质雷泽的分子机制促进哺乳动物胚胎发生的第一细胞命运决策的分子机制的努力。

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