Observation of polymorphic change through analysis of FBRM data: Transformation of paracetamol from form II to form I

Barthe SC; Grover MA; Rousseau RW

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Observation of polymorphic change through analysis of FBRM data: Transformation of paracetamol from form II to form I

机译：通过分析FBRM数据观察多态性变化：对乙酰氨基酚从形式II转变为形式I

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In the present research, batch cooling crystallization of paracetamol from ethanol solutions is used as a model system for exploring the utility of focused beam reflectance measurement (FBRM) data in detection of the formation and/or transformations of polymorphs in situ. Paracetamol is known to exist in three different polymorphic forms. The transition between Form I crystals (octahedrons) and Form II crystals (needle-like) is considered here. Such different shapes generate different chord length densities, and by tracking the chord-length density and the total chord counts through an efficient use of the FBRM, we show that it is possible to monitor the transition from Form II to Form I.

机译：在本研究中，将扑热息痛从乙醇溶液中分批冷却结晶用作模型系统，以探索聚焦光束反射率测量（FBRM）数据在原位多晶型形成和/或转变检测中的实用性。已知扑热息痛以三种不同的多晶型形式存在。这里考虑晶型I晶体（八面体）和晶型II晶体（针状）之间的过渡。这种不同的形状产生不同的和弦长度密度，并且通过有效地使用FBRM跟踪和弦长度密度和总和弦数，我们表明可以监视从II型到I型的过渡。

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《Crystal growth & design》 |2008年第9期|共7页
作者
Barthe SC; Grover MA; Rousseau RW;
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正文语种 eng
中图分类晶体学;
关键词
PARTICLE-SIZE DISTRIBUTION; BEAM REFLECTANCE MEASUREMENT; CHORD LENGTH MEASUREMENTS; ORTHORHOMBIC PARACETAMOL; ETHANOLIC SOLUTION; CRYSTALLIZATION; PSD;

机译：颗粒尺寸分布;束反射率测量;弦长测量;正交甲PA酚;乙醇溶液;结晶;PSD;

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专利

1. Observation of polymorphic change through analysis of FBRM data: Transformation of paracetamol from form II to form I [J] . Barthe SC, Grover MA, Rousseau RW Crystal growth & design . 2008,第9期

机译：通过分析FBRM数据观察多态性变化：对乙酰氨基酚从形式II转变为形式I
2. In Situ Focused Beam Reflectance Measurement (FBRM), Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Raman Characterization of the Polymorphic Transformation of Carbamazepine [J] . Jingkang Wang, Sohrab Rohani, Ying Bao, Pharmaceutics . 2012,第1期

机译：原位聚焦光束反射率测量（FBRM），衰减全反射傅立叶变换红外（ATR-FTIR）和卡马西平多晶型转变的拉曼光谱表征
3. In Situ Monitoring of Polymorphic Transformations Using a Composite Sensor Array of Raman, NIR, and ATR-UV/vis Spectroscopy, FBRM, and PVM for an Intelligent Decision Support System [J] . Simone E., Saleemi A. N., Nagy Z. K. Organic process research & development . 2015,第1期

机译：使用拉曼，NIR和ATR-UV / vis光谱，FBRM和PVM的复合传感器阵列对多态转换进行原位监控，用于智能决策支持系统
4. Polymorphic Transformation of Pravastatin Sodium Monitored Using Combined on-line FBRM and PVM [C] . Jia Chunyan, Yin Qiuxiang, Zhang Meijing, Proceedings of international symposium on crystal engineering and drug delivery system 2009 . 2009

机译：结合在线FBRM和PVM监测普伐他汀钠的多态转化
5. Three studies in Canadian agriculture : 1. Output and input data for Canadian agriculture, 1926-1970. II. Productivity growth in Canadian agriculture, 1946-1970. III. A Canadian agricultural transformation function, 1946-1970 : a dual approach. [D] . Danielson, Robert Stephen. 1975

机译：加拿大农业的三项研究：1. 1926-1970年加拿大农业的输出和输入数据。二。 1946年至1970年，加拿大农业生产率提高。三， 1946-1970年，加拿大的农业转型职能：双重方法。
6. In Situ Focused Beam Reflectance Measurement (FBRM) Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Raman Characterization of the Polymorphic Transformation of Carbamazepine [O] . Yingying Zhao, Ying Bao, Jingkang Wang, 2012

机译：原位聚焦光束反射率测量（FBRM）衰减全反射傅立叶变换红外（ATR-FTIR）和卡马西平多晶型转变的拉曼光谱表征
7. In Situ Focused Beam Reflectance Measurement (FBRM), Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Raman Characterization of the Polymorphic Transformation of Carbamazepine [O] . Sohrab Rohani, Yingying Zhao, Ying Bao, 2012

机译：原位聚焦光束反射测量（FBRm），衰减全反射傅立叶变换红外（aTR-FTIR）和卡马西平多晶相变的拉曼表征

Observation of polymorphic change through analysis of FBRM data: Transformation of paracetamol from form II to form I

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