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首页> 外文期刊>American Journal of Dermatopathology >Analysis of tumor mitotic rate in thin metastatic melanomas compared with thin melanomas without metastasis using both the hematoxylin and eosin and anti-phosphohistone 3 IHC stain
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Analysis of tumor mitotic rate in thin metastatic melanomas compared with thin melanomas without metastasis using both the hematoxylin and eosin and anti-phosphohistone 3 IHC stain

机译：用血管杂环和曙红和曙红和曙红和抗磷酮3 IHC染色，薄转移性黑色素瘤中肿瘤有丝分裂率与薄黑色素瘤相比

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摘要

Studies have suggested that elevated tumor mitotic rate (MR) is linked to overall survival in thin melanoma. Recently, promising data regarding anti-phosphohistone 3 (pHH3) immunohistochemistry and its ability to aid in calculation of MR have emerged. The authors retrospectively analyzed original biopsies from 13 thin melanomas with positive sentinel node (SN) status and 16 thin melanomas with negative SN status. Both anti-pHH3 immunohistochemistry and the hematoxylin and eosin (H&E) stain were used to evaluate MR by 2 dermatopathologists blinded to SN status using the "hot spot" method. Intraclass coefficient values were attained to measure interobserver concordance and reliability of the pHH3 stain. By generating a receiver operating characteristic curve and analyzing the overall area under the curve, pHH3 was found to have good interobserver reliability. The relationship between MR and SN involvement was also evaluated, but this correlation was not statistically significant.
机译：研究表明，肿瘤有丝分裂率升高（MR）与薄黑色素瘤的总生存有关。 最近，有关抗磷酮3（PHH3）免疫组织化学及其有助于计算MR的能力的有前途的数据。 作者回顾性地分析了来自13个薄黑色素瘤的原始活组织检查，用正哨的节点（Sn）状态和16个薄的黑色素瘤，具有阴性状态。 抗pHH3免疫组织化学和血毒素和曙红（H＆E）染色剂用于使用“热点”方法蒙蔽至SN状态的2个皮肤病学家MR。 达到颅内数系计数值以测量Therobserver的一致性和PHH3污渍的可靠性。 通过产生接收器操作特性曲线并分析曲线下的总面积，发现PH3具有良好的Interobserver可靠性。 还评估了先生和Sn参与的关系，但这种相关性并不统计学意义。

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    TharejaS.; ZagerJ.S.; SadhwaniD.; ChenR.; MarzbanS.; JukicD.M.; GlassL.F.; MessinaJ.;

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    Emory University College of Medicine Clinical and Translational Science Institute University of;

    Department of Cutaneous Oncology Sarcoma Program Moffitt Cancer Center Tampa FL United States;

    University of Central Florida College of Medicine Tampa FL United States;

    Biostatistics Core Clinical and Translational Science Institute University of South Florida;

    University of South Florida College of Medicine Tampa FL United States;

    Department of Pathology and Cell Biology University of South Florida Tampa FL United States;

    Department of Dermatology Moffitt Cancer Center Tampa FL United States Department of;

    Department of Pathology Cell Biology and Dermatology University of South Florida Morsani College;

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  • 正文语种 eng
  • 中图分类 皮肤病学与性病学;
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