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首页> 外文期刊>American Journal of Dermatopathology >Glucagonoma-Associated Necrolytic Migratory Erythema: The Broad Spectrum of the Clinical and Histopathological Findings and Clues to the Diagnosis
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Glucagonoma-Associated Necrolytic Migratory Erythema: The Broad Spectrum of the Clinical and Histopathological Findings and Clues to the Diagnosis

机译：葡萄糖神经治疗症状的坏解迁移红斑：临床和组织病理学发现的广泛谱和诊断的线索

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摘要

Necrolytic migratory erythema (NEM) is associated with glucagonoma, an endocrine malignancy of the pancreas. It is a rare and a likely underrecognized paraneoplastic dermatitis. A 38-year-old woman presented to our clinic with a 3-year history of reocurring pruritic skin rashes with increasing intensity. The skin lesions presented with active annular borders, central scaling, and post-inflammatory hyperpigmentation, but also with erosions, pustules, and crusted lesions. Multiple skin biopsies were taken. The workup of the patient revealed a tumor localized in the head of the pancreas, and glucagon serum levels were elevated. Clues to the diagnosis of NEM were the waxing and waning of serpiginous erythemas with active borders localized on extremities, intertriginous areas, and face. On histopathology, dyskeratosis in all layers of the epidermis were an early feature of NEM, and long-standing lesions typically showed psoriasiform hyperplasia with pallor and necrosis of upper epidermal layers. Clinicians and histopathologists need to be aware of the wide spectrum of skin manifestations in glucagonoma. Early diagnosis of the tumor is crucial for patients.
机译：坏溶解的迁徙红斑（NEM）与葡聚糖组织有关，胰腺的内分泌恶性肿瘤有关。这是一种罕见的颅内骨质皮肤病性皮炎。一名38岁的女子介绍了我们的诊所，历史为3年历史，历史悠久的瘙痒皮疹随着强度的增加。皮肤病变具有主动环形边框，中央缩放和后炎症性高沉想，还具有糜烂，脓疱和裂纹病变。采取了多种皮肤活组织检查。患者的后处理揭示了胰腺头部的肿瘤，并且胰高血清水平升高。 NEM诊断的线索是血磷红斑的打蜡和衰落，其活性边界本地化在四肢，中继区域和面部。关于组织病理学，表皮的所有层中的渗滤病是NEM的早期特征，长站病变通常与上表皮层的粘性和坏死进行牛皮癣增生。临床医生和组织病理学家需要了解葡萄糖神经内容的广泛皮肤表现。肿瘤的早期诊断对于患者至关重要。

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