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首页> 外文期刊>American Journal of Dermatopathology >CyclinD1 Is Useful to Differentiate Langerhans Cell Histiocytosis From Reactive Langerhans Cells
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CyclinD1 Is Useful to Differentiate Langerhans Cell Histiocytosis From Reactive Langerhans Cells

机译：Cyclind1可用于区分兰培兰细胞组织细胞毒性来自反应性朗格汉儿细胞

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摘要

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder characterized by clonal proliferation of neoplastic Langerhans cells (LCs). LC proliferation can also be seen in different reactive dermatosis. CyclinD1 is a downstream marker of mitogen-activated protein (MAP) kinase pathway, which is often activated in LCH. This study aimed to evaluate the role of cyclinD1 to differentiate reactive LC proliferation from LCH. All cases of cutaneous LCH diagnosed by biopsy in the past 3 years (n = 13) were immunostained with CD1a, p53, CD31, and cyclinD1. Seven cases each of discoid lupus erythematosus (DLE) and lichen planus (LP) were taken as control. Presence of p53, CD31, and cyclinD1-positive LCs (CD1a-positive) were compared in the dermis. In all LCH cases, dermal neoplastic LCs showed diffuse CD1a positivity and 12 cases (92.3%) showed variable (30%-70%) cyclinDl expression. Weak p53 and CD31 expression were seen in 61.5% and 46.1% of LCH cases, respectively. In the control group, 5 cases of LP and 4 cases of DLE showed variable LC proliferation, highlighted by CD1a positivity. However, no case of reactive dermatosis showed cyclinD1 or p53 expression by the reactive LCs. Weak and patchy CD31 expression by the reactive LCs were found in 1 (25%) and 2 (40%) cases of DLE and LP, respectively. To conclude, cyclinDl is frequently expressed in neoplastic LCs in LCH. It is an efficient marker to differentiate neoplastic from reactive LC proliferation, and can be used as a surrogate marker in LCH.
机译：朗格汉斯细胞组织细胞症（LCH）是一种稀有的组织细胞紊乱，其特征在于肿瘤朗格汉斯细胞（LCS）的克隆增殖。在不同的活性皮肤病中也可以看到LC增殖。 Cyclind1是丝裂原激活蛋白（MAP）激酶途径的下游标记，其通常在LCH中被激活。本研究旨在评估Cyclind1对来自LCH的反应性LC增殖的作用。过去3年（n = 13）在过去3年（n = 13）中诊断的所有皮肤淋浴含量用CD1a，p53，cd31和cyclind1免疫染色。七种案例，每种盘状狼疮红斑（DLE）和地衣平面（LP）被视为对照。在真皮中比较了P53，CD31和CyclinD1阳性LCs（CD1A阳性）。在所有LCH患者中，皮肤肿瘤LCS显示弥漫性CD1A阳性，12例（92.3％）显示出可变的（30％-70％）Cyclindl表达。弱P53和CD31表达分别以61.5％和46.1％的LCH病例观察。在对照组中，5例LP和4例DLE显示可变性LC增殖，CD1A阳性突出显示。然而，没有反应性皮肤病的任何情况显示反应性LCS的Cyclind1或P53表达。反应性LCs的弱和斑态CD31表达分别在1（25％）和2（40％）的DLE和LP中发现。为了得出结论，Cyclindl经常在LCH中以肿瘤LCS表达。它是一种有效的标记，用于将肿瘤从反应性LC增殖区分，并且可以用作LCH中的替代标记物。

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