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首页> 外文期刊>American Journal of Nephrology >Tubular Cell Senescence in the Donated Kidney Predicts Allograft Function, but Not Donor Remnant Kidney Function, in Living Donor Kidney Transplantation
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Tubular Cell Senescence in the Donated Kidney Predicts Allograft Function, but Not Donor Remnant Kidney Function, in Living Donor Kidney Transplantation

机译：捐赠的肾脏中的管状细胞衰老预测同种异体移植功能，但不是供体残留的肾功能，在生活供体肾移植中

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Background: It is uncertain whether kidneys from marginal donors are suitable for live kidney transplantation. In deceased donor kidneys, tubular cell senescence affects allograft function. However, the degree of cell senescence in a living donor kidney with marginal factors has not been reported. In this study, we assessed the association of tubular cell senescence with allograft and remnant kidney function by a prospective observational clinical study. Methods: Thirty-eight living donor kidney transplantations were analyzed prospectively. Tissue sections obtained from preimplantation kidney biopsies were immunostained for p16 INK4a to indicate cell senescence. Various kidney biomarkers were analyzed in urine and blood samples. Results: Of the 38 donors, 21 had marginal factors. Severe tubular senescence was found in living donors with overlapping marginal criteria. Tubular senescence in living donor kidneys was significantly related to donor age and lower recipient kidney function at 1 year after transplantation independently of donor age (β?= –0.281; p ?= 0.050) but did not affect remnant kidney function after donation. Pretransplantation donor pre-estimated glomerular filtration rate and hypertension did not show a significant area under the curve (AUC) for prediction of high tubular senescence. High plasma levels of soluble αKlotho were associated with a higher predictive value for low tubular cell senescence with an AUC of 0.78 (95% CI 0.62–0.93; p ? Conclusions: The nuclear p16-staining rate in donated kidney tubules is a predictor for allograft kidney function but not donor remnant kidney function. Detection of tubular cell senescence may facilitate selection of appropriate living donor candidates.
机译：背景：不确定来自边缘捐赠者的肾脏是否适合活肾移植。在死亡的供体肾脏中，管状细胞衰老会影响同种异体移植功能。然而，尚未报告具有边缘因素的活体供体肾中的细胞衰老程度。在这项研究中，我们通过前瞻性观察临床研究评估了对同种异体移植和残余肾功能的管状细胞衰老的关联。方法：前瞻性分析了三十八个活体肾移植。从肾上腺化肾活检获得的组织切片对于P16 Ink4A免疫染色，以表明细胞衰老。在尿液和血液样品中分析了各种肾脏生物标志物。结果：38个捐助者，21例有边缘因素。在具有重叠边缘标准的生活捐赠者中发现了严重的管状衰老。活体肾脏的管状衰老与供体年龄的移植后1年内与供体年龄和降低受体肾功能显着相关（β？= -0.281; p？= 0.050），但在捐赠后没有影响残留的肾功能。预甲醚供体预估计的肾小球过滤速率和高血压在曲线（AUC）下没有显示出高管衰老的曲线（AUC）。高血浆水平的可溶性αklotho与低管状细胞衰老的较高预测值与0.78的AUC（95％CI 0.62-0.93; P？结论：捐赠肾小管中的核P16染色率是同种异体移植的预测因子肾功能但不是供体残留的肾功能。管状细胞衰老的检测可以促进选择适当的活体候选者。

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