...
首页> 外文期刊>Acta neurobiologiae experimentalis >Expression of Angiopoietin-1 and the receptor Tie-2 mRNA in rat brains following intracerebral hemorrhage.
【24h】

Expression of Angiopoietin-1 and the receptor Tie-2 mRNA in rat brains following intracerebral hemorrhage.

机译:脑出血后大鼠脑中Angiopoietin-1和受体Tie-2 mRNA的表达。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       

摘要

Angiopoietin-1 (Ang-1) belongs to a novel family of endothelial growth factors that function as ligands for an endothelialspecific receptor tyrosine kinase (Tie-2). The Ang-/Tie-2 system may contribute to angiogenesis and vascular remodeling by mediating interactions of endothelial cells with smooth muscle cells and pericytes. The spatial distribution and temporal expression of Ang-1 and Tie-2 in the rat brain were studied following collagenase-induced intracerebral hemorrhage (ICH) by immunohistochemistry and reverse transcription-polymerase chain (RT-PCR) analysis, respectively. Immunohistochemical analysis revealed that some Ang-1 or Tie-2-positive dilated vessels resided around the hematoma and extended into the clot. RT-PCR analysis showed that Ang-1 and Tie-2 mRNA signal was detected at 2 days and persisted for 28 days after ICH. These findings suggest that ICH could lead to upregulation of Ang-1 and the receptor Tie-2 mRNA.
机译:血管生成素-1(Ang-1)属于一个新的内皮生长因子家族,可作为内皮特异性受体酪氨酸激酶(Tie-2)的配体。 Ang- / Tie-2系统可能通过介导内皮细胞与平滑肌细胞和周细胞的相互作用来促进血管生成和血管重塑。分别通过免疫组织化学和逆转录聚合酶链反应(RT-PCR)分析胶原酶诱导的脑出血(ICH)后Ang-1和Tie-2在大鼠脑中的空间分布和时间表达。免疫组织化学分析显示,一些Ang-1或Tie-2阳性扩张血管位于血肿周围,并延伸到血凝块中。 RT-PCR分析显示ICH后2天检测到Ang-1和Tie-2 mRNA信号,并持续28天。这些发现表明ICH可能导致Ang-1和受体Tie-2 mRNA的上调。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号