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首页> 外文期刊>Acta neurobiologiae experimentalis >Exogenous hydrogen sulfide produces hemodynamic effects by triggering central neuroregulatory mechanisms.
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Exogenous hydrogen sulfide produces hemodynamic effects by triggering central neuroregulatory mechanisms.

机译：外源性硫化氢通过触发中枢神经调节机制产生血液动力学效应。

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摘要

Recently, it was found that hydrogen sulfide (H2S) may serve as an important transmitter in peripheral organs as well as in the brain. The aim of the present study was to evaluate the possible function of H2S in the brain regulation of the circulatory system. Experiments were performed on conscious, male, Wistar-Kyoto rats. Mean arterial blood pressure (MABP) and heart rate (HR) were recorded continuously under baseline conditions and during infusions into the lateral cerebral ventricle (LCV) of the experimental animals. In control series LCV infusion of vehicle (Krebs-Henseleit bicarbonate-buffer) did not cause significant changes in MABP or HR. LCV infusion of H2S donor (NaHS) at the rate of 400 n/h resulted in an increase in MABP, whereas infusions at the rate of 100 n/h and 200 n/h failed to change MABP. On the other hand LCV infusion of H2S donor at the rate of 200 n/h caused a significant increase in HR while infusion at the rate of 400 n/h produced an increase in HR, which was smaller than this observed during infusion at the rate of 200 n/h. H2S donor administered at the rate of 100 n/h failed to affect HR. In conclusion, the present study demonstrates that exogenous hydrogen sulfide changes hemodynamic parameters by centrally mediated mechanisms. The hemodynamic effect seems to be dependent on H2S concentration in cerebrospinal fluid. It appears that the hypertensive response may occur at a concentration, which does not exceed twice the physiological level.
机译：最近，人们发现硫化氢（H2S）可能在周围器官以及大脑中起重要的传递作用。本研究的目的是评估H2S在循环系统的大脑调节中的可能功能。实验是在有意识的雄性Wistar-Kyoto大鼠上进行的。在基线条件下以及在注入实验动物的脑侧脑室（LCV）期间连续记录平均动脉血压（MABP）和心率（HR）。在对照系列中，LCV媒介物（Krebs-Henseleit碳酸氢盐缓冲液）的输注并未引起MABP或HR的显着变化。 LCV以400 n / h的速率输注H2S供体（NaHS）导致MABP升高，而以100 n / h和200 n / h的速率输注不能改变MABP。另一方面，以200 n / h的速率对H2S供体进行LCV输注会导致HR显着增加，而以400 n / h的速率进行输注会导致HR的增加，该速率小于以该速率进行输注时观察到的200 n / h。以100 n / h的速度施用H2S供体未能影响HR。总之，本研究证明外源性硫化氢通过中央介导的机制改变了血液动力学参数。血流动力学效应似乎取决于脑脊液中H2S的浓度。看来高血压反应的浓度可能不超过生理水平的两倍。

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