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首页> 外文期刊>Acta neurobiologiae experimentalis >Differentiations of the effect of NMDA on the spatial learning of rats with 4 and 12 week diabetes mellitus.
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Differentiations of the effect of NMDA on the spatial learning of rats with 4 and 12 week diabetes mellitus.

机译：NMDA对4周和12周糖尿病大鼠空间学习的影响的差异。

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This study examines possible interactions between behavioral effects and influence of N-methyl-D-aspartate acid (NMDA) receptors in 4 and 12-week streptozotocin (STZ) induced diabetic rats. Effects of NMDA receptor agonist on spatial learning were tested in control groups of rats and in rats with 4 and 12 weeks diabetes mellitus (DM). Experimental diabetes was induced by a single intravenous injection of streptozotocin at a dose of 65 m/kg, dissolved in citrate buffer. We used the water maze task and examined the acquisition and the retrieval of spatial memory in rats. In our present experiments, we observed that DM had no significant influence on acquisition and retrieval in 4 week diabetic rats on Morris water maze, but impaired examined parameters in 12 week diabetic rats in this test. The NMDA receptor agonist did not influence acquisition but increased recall on water maze in 12 week streptozotocin diabetic rats.
机译：这项研究检查了行为和影响的4和12周链脲佐菌素（STZ）诱导的糖尿病大鼠中N-甲基-D-天冬氨酸（NMDA）受体之间可能的相互作用。在对照组大鼠以及患有4和12周糖尿病（DM）的大鼠中测试了NMDA受体激动剂对空间学习的影响。实验性糖尿病是通过单次静脉内注射溶解在柠檬酸盐缓冲液中的链脲佐菌素剂量为65 m / kg诱导的。我们使用了水迷宫任务，并检查了大鼠空间记忆的获取和恢复。在我们目前的实验中，我们观察到DM对4周糖尿病大鼠在Morris水迷宫上的获取和恢复没有显着影响，但是在该试验中损害了12周糖尿病大鼠的检查参数。 NMDA受体激动剂不会影响获取，但会增加12周链脲佐菌素糖尿病大鼠对水迷宫的记忆。

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