• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta Neurochirurgica >Longitudinal changes in seizure outcomes after resection of cerebral cavernous malformations in patients presenting with seizures: A long-term follow-up of 46 patients
【24h】

Longitudinal changes in seizure outcomes after resection of cerebral cavernous malformations in patients presenting with seizures: A long-term follow-up of 46 patients

机译：癫痫发作患者切除脑海绵状畸形后癫痫发作结局的纵向变化：46例患者的长期随访

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Seizure is the most common presentation in patients with cerebral cavernous malformations (CCMs). Although many articles have documented seizure outcomes after resection of CCM, few have conducted long-term follow-ups; thus, the fluctuating seizure outcomes have been neglected. The purpose of this study is to describe long-term postoperative seizure outcomes in patients with CCM and to compare seizure outcomes between patients with sporadic seizures and those with chronic seizures. Methods: Forty-six patients with CCM presenting with seizures underwent surgery. The male-to-female ratio was 1:1, and the average age at initial seizure onset was 27.6 years. The mean preoperative seizure duration was 42.7 months. Patients were divided into two groups: a chronic group (N=20) and a sporadic group (N=26) according to seizure frequency and duration. The mean postoperative follow-up duration was 96.3 months, and the postoperative seizure outcomes were checked annually based upon Engel's classification. Results: After the first year of follow-up, 80.8 % of the sporadic group and 75.0 % of the chronic group were evaluated as Engel class I. These rates increased to 100.0 % and 90.0 %, respectively, at the eighth year of follow-up. Overall, 29 (63.0 %) of the 46 patients experienced changes in seizure outcomes over the follow-up period. Despite their delayed improvements, the chronic group showed less favorable outcomes throughout follow-up (p=0.025). Conclusions: Long-term follow-up is indispensable for accurately assessing postoperative seizure outcomes because these outcomes change continuously. We recommend earlier surgery to achieve seizure-free status in patients with CCM. However, even in the chronic group, surgery is recommended, considering the overall delayed improvement.
机译：背景：癫痫是脑海绵状畸形（CCM）患者最常见的表现。尽管有许多文章记录了切除CCM后的癫痫发作结果，但很少进行长期随访。因此，癫痫发作结果的波动已被忽略。这项研究的目的是描述CCM患者的长期术后癫痫发作结果，并比较散发性癫痫患者和慢性癫痫患者的癫痫发作结果。方法：四十六例患有癫痫发作的CCM患者接受了手术治疗。男女比例为1：1，开始发作时的平均年龄为27.6岁。术前平均癫痫发作时间为42.7个月。根据发作频率和持续时间将患者分为两组：慢性组（N = 20）和散发组（N = 26）。术后平均随访时间为96.3个月，并根据Engel的分类每年检查一次术后癫痫发作的结局。结果：随访的第一年，散发组的80.8％和慢性组的75.0％被评估为Engel I级。在随访的第八年，这些比率分别增加到100.0％和90.0％，向上。总体而言，在随访期间，46例患者中有29例（63.0％）的癫痫发作发生了变化。尽管其延迟改善，但慢性组在整个随访过程中均显示出较差的预后（p = 0.025）。结论：长期随访对于准确评估术后癫痫发作的结果是必不可少的，因为这些结果会不断变化。我们建议早期手术以使CCM患者达到无癫痫状态。但是，即使在慢性组中，考虑到总体延迟的改善，建议进行手术。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号